Total Synthesis of Herbimycin A

Masaya Nakata, Tomomasa Osumi, Ari Ueno, Takenori Kimura, Tetsuro Tamai, Kuniaki Tatsuta

Research output: Contribution to journalArticle

49 Citations (Scopus)


The first total synthesis of herbimycin A (1), the benzoquinoid ansamycin antibiotic, has been accomplished by coupling two segments of the aliphatic ansa-chain 2 and the aromatic chromophore 3, elucidating the absolute stereochemistry.

Original languageEnglish
Pages (from-to)6015-6018
Number of pages4
JournalTetrahedron Letters
Issue number42
Publication statusPublished - 1991 Oct 14


  • Ansamycin Antibiotic
  • Herbimycin A
  • Regioselective Epoxide-ring Opening
  • Stereoselective Hydroboration
  • [(Z-γ-Methoxyallyl]diisopinocampheylborane

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Nakata, M., Osumi, T., Ueno, A., Kimura, T., Tamai, T., & Tatsuta, K. (1991). Total Synthesis of Herbimycin A. Tetrahedron Letters, 32(42), 6015-6018.