The first total synthesis of herbimycin A (1), the benzoquinoid ansamycin antibiotic, has been accomplished by coupling two segments of the aliphatic ansa-chain 2 and the aromatic chromophore 3, elucidating the absolute stereochemistry.
- Ansamycin Antibiotic
- Herbimycin A
- Regioselective Epoxide-ring Opening
- Stereoselective Hydroboration
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry