Total synthesis of hygromycin A

Noritaka Chida; Masami Ohtsuka; Keiichi Nakazawa; Seiichiro Ogawa

doi:10.1039/C39890000436

Total synthesis of hygromycin A

Noritaka Chida, Masami Ohtsuka, Keiichi Nakazawa, Seiichiro Ogawa

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The first complete synthesis of antibiotic hygromycin A is reported; coupling of the protected sugar moiety (2) and the aminocyclitol (3) derived from D-glucose as the optically active from, followed by deprotection, gives the product (1) which was identified with an aunthentic sample by 400 MHz ¹H n.m.r. spectroscopy.

Original language	English
Pages (from-to)	436-438
Number of pages	3
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	7
DOIs	https://doi.org/10.1039/C39890000436
Publication status	Published - 1989 Jan 1

ASJC Scopus subject areas

Molecular Medicine

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10.1039/C39890000436

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title = "Total synthesis of hygromycin A",

abstract = "The first complete synthesis of antibiotic hygromycin A is reported; coupling of the protected sugar moiety (2) and the aminocyclitol (3) derived from D-glucose as the optically active from, followed by deprotection, gives the product (1) which was identified with an aunthentic sample by 400 MHz 1H n.m.r. spectroscopy.",

author = "Noritaka Chida and Masami Ohtsuka and Keiichi Nakazawa and Seiichiro Ogawa",

year = "1989",

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doi = "10.1039/C39890000436",

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AU - Nakazawa, Keiichi

AU - Ogawa, Seiichiro

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AB - The first complete synthesis of antibiotic hygromycin A is reported; coupling of the protected sugar moiety (2) and the aminocyclitol (3) derived from D-glucose as the optically active from, followed by deprotection, gives the product (1) which was identified with an aunthentic sample by 400 MHz 1H n.m.r. spectroscopy.

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Total synthesis of hygromycin A

Abstract

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