Total synthesis of hygromycin A

Noritaka Chida, Masami Ohtsuka, Keiichi Nakazawa, Seiichiro Ogawa

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The first complete synthesis of antibiotic hygromycin A is reported; coupling of the protected sugar moiety (2) and the aminocyclitol (3) derived from D-glucose as the optically active from, followed by deprotection, gives the product (1) which was identified with an aunthentic sample by 400 MHz 1H n.m.r. spectroscopy.

Original languageEnglish
Pages (from-to)436-438
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number7
DOIs
Publication statusPublished - 1989 Jan 1

ASJC Scopus subject areas

  • Molecular Medicine

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