Total synthesis of hygromycin A

Noritaka Chida, Masami Ohtsuka, Keiichi Nakazawa, Seiichiro Ogawa

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The first complete synthesis of antibiotic hygromycin A is reported; coupling of the protected sugar moiety (2) and the aminocyclitol (3) derived from D-glucose as the optically active from, followed by deprotection, gives the product (1) which was identified with an aunthentic sample by 400 MHz 1H n.m.r. spectroscopy.

Original languageEnglish
Pages (from-to)436-438
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number7
DOIs
Publication statusPublished - 1989

Fingerprint

Antibiotics
Sugars
Glucose
Spectrum Analysis
Spectroscopy
Anti-Bacterial Agents
hygromycin A
coupling sugar

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Total synthesis of hygromycin A. / Chida, Noritaka; Ohtsuka, Masami; Nakazawa, Keiichi; Ogawa, Seiichiro.

In: Journal of the Chemical Society, Chemical Communications, No. 7, 1989, p. 436-438.

Research output: Contribution to journalArticle

Chida, Noritaka ; Ohtsuka, Masami ; Nakazawa, Keiichi ; Ogawa, Seiichiro. / Total synthesis of hygromycin A. In: Journal of the Chemical Society, Chemical Communications. 1989 ; No. 7. pp. 436-438.
@article{a7d6ce0815664742839f4a0921c32692,
title = "Total synthesis of hygromycin A",
abstract = "The first complete synthesis of antibiotic hygromycin A is reported; coupling of the protected sugar moiety (2) and the aminocyclitol (3) derived from D-glucose as the optically active from, followed by deprotection, gives the product (1) which was identified with an aunthentic sample by 400 MHz 1H n.m.r. spectroscopy.",
author = "Noritaka Chida and Masami Ohtsuka and Keiichi Nakazawa and Seiichiro Ogawa",
year = "1989",
doi = "10.1039/C39890000436",
language = "English",
pages = "436--438",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "7",

}

TY - JOUR

T1 - Total synthesis of hygromycin A

AU - Chida, Noritaka

AU - Ohtsuka, Masami

AU - Nakazawa, Keiichi

AU - Ogawa, Seiichiro

PY - 1989

Y1 - 1989

N2 - The first complete synthesis of antibiotic hygromycin A is reported; coupling of the protected sugar moiety (2) and the aminocyclitol (3) derived from D-glucose as the optically active from, followed by deprotection, gives the product (1) which was identified with an aunthentic sample by 400 MHz 1H n.m.r. spectroscopy.

AB - The first complete synthesis of antibiotic hygromycin A is reported; coupling of the protected sugar moiety (2) and the aminocyclitol (3) derived from D-glucose as the optically active from, followed by deprotection, gives the product (1) which was identified with an aunthentic sample by 400 MHz 1H n.m.r. spectroscopy.

UR - http://www.scopus.com/inward/record.url?scp=0024565707&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024565707&partnerID=8YFLogxK

U2 - 10.1039/C39890000436

DO - 10.1039/C39890000436

M3 - Article

SP - 436

EP - 438

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 7

ER -