Total synthesis of (-)-mniopetal E, a novel biologically intriguing drimane sesquiterpenoid

Yoshikazu Suzuki, Ryoko Nishimaki, Makoto Ishikawa, Takeshi Murata, Ken ichi Takao, Kin ichi Tadano

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Total synthesis of (-)-mniopetal E, the common skeleton of the biologically intriguing mniopetals A-D, was accomplished for the first time. The key step of the total synthesis was stereoselective intramolecular Diels-Alder reaction for construction of the octahydronaphthalene core structure. Our total synthesis as natural enantiomeric form established the unsettled absolute stereochemistry of the antibiotic.

Original languageEnglish
Pages (from-to)7835-7838
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number44
DOIs
Publication statusPublished - 1999 Oct 29

Keywords

  • Biologically active compounds
  • Diels-Alder reactions
  • Terpenoids

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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