Total synthesis of murrastifoline-A by way of the Pd-catalyzed double N-arylation of a carbazolamine with a 2,2′-dibromobiphenyl derivative

Takafumi Kitawaki, Yoko Hayashi, Noritaka Chida

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The first total synthesis of murrastifoline-A (1), a biscarbazole alkaloid is described. The biscarbazole skeleton of 1 was effectively constructed by the Pd-catalyzed double N-arylation of carbazolamine (bottom-half segment, 3) with dibromobiphenyl derivative (top-half segment, 2) in one-step reaction. Both segments were synthesized starting from 2-amino-5-methylphenol (4).

Original languageEnglish
Pages (from-to)1561-1567
Number of pages7
JournalHeterocycles
Volume65
Issue number7
DOIs
Publication statusPublished - 2005 Jul 1

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Alkaloids
Skeleton
Derivatives
murrastifoline-A
2-amino-5-methylphenol

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Total synthesis of murrastifoline-A by way of the Pd-catalyzed double N-arylation of a carbazolamine with a 2,2′-dibromobiphenyl derivative. / Kitawaki, Takafumi; Hayashi, Yoko; Chida, Noritaka.

In: Heterocycles, Vol. 65, No. 7, 01.07.2005, p. 1561-1567.

Research output: Contribution to journalArticle

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