Total synthesis of (±)-murrayazoline

Akiko Ueno, Takafumi Kitawaki, Noritaka Chida

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The total synthesis of (±)-murrayazoline (1) is described. The characteristic hexa-heterocyclic structure of 1 was constructed by a combination of the intramolecular Friedel-Crafts-type Michael addition and Pd-catalyzed C-O coupling reactions. The N-substituted carbazole component was synthesized in one pot by the double N-arylation of a sterically hindered amine with a dibromobiphenyl derivative.

Original languageEnglish
Pages (from-to)1999-2002
Number of pages4
JournalOrganic Letters
Volume10
Issue number10
DOIs
Publication statusPublished - 2008 May 15

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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