Total synthesis of naturally occurring chiral cyclopropane fatty acids and related compounds

Shinsuke Inuki; Yukari Fujimoto

doi:10.1016/j.tetlet.2019.03.043

Total synthesis of naturally occurring chiral cyclopropane fatty acids and related compounds

Shinsuke Inuki, Yukari Fujimoto

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Cyclopropane fatty acids (CFAs) and related compounds containing CFAs commonly occur in various natural sources, including plants or microorganisms. Some CFAs exhibit intriguing biological activities such as antifungal or immunosuppressive activities. Due to their biological importance and structural features, a number of synthetic studies have been conducted to date. These total syntheses have helped to elucidate their structural determinants or biological activities. Herein the total syntheses of naturally occurring CFAs and related compounds are summarized.

Original language	English
Pages (from-to)	1083-1090
Number of pages	8
Journal	Tetrahedron Letters
Volume	60
Issue number	16
DOIs	https://doi.org/10.1016/j.tetlet.2019.03.043
Publication status	Published - 2019 Apr 18

Keywords

Biological activity
Cyclopropane fatty acid
Structural determination
Total synthesis

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2019.03.043

Cite this

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title = "Total synthesis of naturally occurring chiral cyclopropane fatty acids and related compounds",

abstract = "Cyclopropane fatty acids (CFAs) and related compounds containing CFAs commonly occur in various natural sources, including plants or microorganisms. Some CFAs exhibit intriguing biological activities such as antifungal or immunosuppressive activities. Due to their biological importance and structural features, a number of synthetic studies have been conducted to date. These total syntheses have helped to elucidate their structural determinants or biological activities. Herein the total syntheses of naturally occurring CFAs and related compounds are summarized.",

keywords = "Biological activity, Cyclopropane fatty acid, Structural determination, Total synthesis",

author = "Shinsuke Inuki and Yukari Fujimoto",

note = "Funding Information: This research was financially supported by grants from the JSPS KAKENHI (Nos. JP26282211 , JP26102732 , JP16K16638 and JP17H02207 ). Funding Information: This research was financially supported by grants from the JSPS KAKENHI (Nos. JP26282211, JP26102732, JP16K16638 and JP17H02207).",

year = "2019",

month = apr,

day = "18",

doi = "10.1016/j.tetlet.2019.03.043",

language = "English",

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journal = "Tetrahedron Letters",

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T1 - Total synthesis of naturally occurring chiral cyclopropane fatty acids and related compounds

AU - Inuki, Shinsuke

AU - Fujimoto, Yukari

N1 - Funding Information: This research was financially supported by grants from the JSPS KAKENHI (Nos. JP26282211 , JP26102732 , JP16K16638 and JP17H02207 ). Funding Information: This research was financially supported by grants from the JSPS KAKENHI (Nos. JP26282211, JP26102732, JP16K16638 and JP17H02207).

PY - 2019/4/18

Y1 - 2019/4/18

N2 - Cyclopropane fatty acids (CFAs) and related compounds containing CFAs commonly occur in various natural sources, including plants or microorganisms. Some CFAs exhibit intriguing biological activities such as antifungal or immunosuppressive activities. Due to their biological importance and structural features, a number of synthetic studies have been conducted to date. These total syntheses have helped to elucidate their structural determinants or biological activities. Herein the total syntheses of naturally occurring CFAs and related compounds are summarized.

AB - Cyclopropane fatty acids (CFAs) and related compounds containing CFAs commonly occur in various natural sources, including plants or microorganisms. Some CFAs exhibit intriguing biological activities such as antifungal or immunosuppressive activities. Due to their biological importance and structural features, a number of synthetic studies have been conducted to date. These total syntheses have helped to elucidate their structural determinants or biological activities. Herein the total syntheses of naturally occurring CFAs and related compounds are summarized.

KW - Biological activity

KW - Cyclopropane fatty acid

KW - Structural determination

KW - Total synthesis

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DO - 10.1016/j.tetlet.2019.03.043

M3 - Review article

AN - SCOPUS:85063267352

SN - 0040-4039

VL - 60

SP - 1083

EP - 1090

JO - Tetrahedron Letters

JF - Tetrahedron Letters

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ER -

Total synthesis of naturally occurring chiral cyclopropane fatty acids and related compounds

Abstract

Keywords

ASJC Scopus subject areas

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