Total synthesis of nucleoside antibiotics possessing novel N-glycoside structures

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Construction of aryl and heteroaryl N-glycoside structures by way of the palladium-catalyzed Buchwald-Hartwig N-arylation of pyranosylamines with aryl and heteroaryl halide derivatives is described. This methodology was successfully applied to the total synthesis of nucleoside antibiotics, spicamycin and dapiramicin B, possessing novel heteroaryl N-glycosides. Kinetic and thermodynamic analyses of heteroaryl N-glycosides are also reported.

Original languageEnglish
Pages (from-to)1105-1115
Number of pages11
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume66
Issue number11
DOIs
Publication statusPublished - 2008 Nov

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint Dive into the research topics of 'Total synthesis of nucleoside antibiotics possessing novel N-glycoside structures'. Together they form a unique fingerprint.

  • Cite this