Total synthesis of (-)-PA-48153C (pironetin) utilising L-quebrachitol as a chiral building block

Noritaka Chida, Mitsukane Yoshinaga, Takahiko Tobe, Seiichiro Ogawa

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The chiral and stereoselective synthesis of (-)-PA-48153C (pironetin) 1, a novel immunosuppressant, is described; the acyclic portion possessing four contiguous chiral centres in 1 was constructed stereoselectively from L-quebrachitol and the 2-pyranone moiety was prepared from L-malic acid.

Original languageEnglish
Pages (from-to)1043-1044
Number of pages2
JournalChemical Communications
Issue number11
Publication statusPublished - 1997

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Acids
Immunosuppressive Agents
quebrachitol
pironetin
malic acid

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Total synthesis of (-)-PA-48153C (pironetin) utilising L-quebrachitol as a chiral building block. / Chida, Noritaka; Yoshinaga, Mitsukane; Tobe, Takahiko; Ogawa, Seiichiro.

In: Chemical Communications, No. 11, 1997, p. 1043-1044.

Research output: Contribution to journalArticle

Chida, Noritaka ; Yoshinaga, Mitsukane ; Tobe, Takahiko ; Ogawa, Seiichiro. / Total synthesis of (-)-PA-48153C (pironetin) utilising L-quebrachitol as a chiral building block. In: Chemical Communications. 1997 ; No. 11. pp. 1043-1044.
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