Total synthesis of (-)-PA-48153C (pironetin) utilising L-quebrachitol as a chiral building block

Noritaka Chida, Mitsukane Yoshinaga, Takahiko Tobe, Seiichiro Ogawa

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The chiral and stereoselective synthesis of (-)-PA-48153C (pironetin) 1, a novel immunosuppressant, is described; the acyclic portion possessing four contiguous chiral centres in 1 was constructed stereoselectively from L-quebrachitol and the 2-pyranone moiety was prepared from L-malic acid.

Original languageEnglish
Pages (from-to)1043-1044
Number of pages2
JournalChemical Communications
Issue number11
DOIs
Publication statusPublished - 1997 Jan 1

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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