Total synthesis of phenoxan and a related pyrone derivative

Yasuharu Ishibashi, Shigeru Ohba, Shigeru Nishiyama, Shosuke Yamamura

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39 Citations (Scopus)

Abstract

Phenoxan, HIV-1 inhibitor isolated from the myxobacteria, has been synthesized in 16 steps starting from ethyl 2-methylacetoacetate. The related isomer corresponding to the oxazole part was also obtained via an orthoester-enediol rearrangement.

Original languageEnglish
Pages (from-to)2997-3000
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number17
DOIs
Publication statusPublished - 1996 Apr 22

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Ishibashi, Y., Ohba, S., Nishiyama, S., & Yamamura, S. (1996). Total synthesis of phenoxan and a related pyrone derivative. Tetrahedron Letters, 37(17), 2997-3000. https://doi.org/10.1016/0040-4039(96)00483-2