Total synthesis of (+)-polyoxin J starting from myo-inositol

Noritaka Chida, Kazue Koizumi, Yoko Kitada, Chiaki Yokoyama, Seiichiro Ogawa

Research output: Contribution to journalArticle

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Abstract

The total synthesis of the antifungal antibiotic, polyoxin J 1 starting from myo-inositol is described; the two key components, 2 and 3, were prepared from a pair of optically resolved myo-inositol derivatives 4L and 4D, respectively, using a highly regioselective Baeyer-Villiger reaction, and finally coupled to complete the total synthesis.

Original languageEnglish
Pages (from-to)111-113
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number1
DOIs
Publication statusPublished - 1994

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Inositol
Antifungal Agents
Antibiotics
Derivatives
polyoxin

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Total synthesis of (+)-polyoxin J starting from myo-inositol. / Chida, Noritaka; Koizumi, Kazue; Kitada, Yoko; Yokoyama, Chiaki; Ogawa, Seiichiro.

In: Journal of the Chemical Society, Chemical Communications, No. 1, 1994, p. 111-113.

Research output: Contribution to journalArticle

Chida, Noritaka ; Koizumi, Kazue ; Kitada, Yoko ; Yokoyama, Chiaki ; Ogawa, Seiichiro. / Total synthesis of (+)-polyoxin J starting from myo-inositol. In: Journal of the Chemical Society, Chemical Communications. 1994 ; No. 1. pp. 111-113.
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