Total synthesis of (-)-samaderine Y from (S)-(+)-carvone

Tony K.M. Shing; Ying Y. Yeung

doi:10.1002/anie.200502763

Total synthesis of (-)-samaderine Y from (S)-(+)-carvone

Tony K.M. Shing, Ying Y. Yeung

Department of Chemistry

Research output: Contribution to journal › Article

25 Citations (Scopus)

Abstract

(Chemical Equation Presented) Elegant, efficient, and enantiospecific describe the first total synthesis of the quassinoid (-)-samaderine Y (see scheme), which has been shown to display in vitro cytotoxicity and is of interest as a potential antitumor agent. Its synthesis has been accomplished from (S)-(+)-carvone in 21 steps.

Original language	English
Pages (from-to)	7981-7984
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	44
Issue number	48
DOIs	https://doi.org/10.1002/anie.200502763
Publication status	Published - 2005 Dec 9

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Keywords

Antitumor agents
Fused-ring systems
Natural products
Quassinoids
Total synthesis

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Cite this

Shing, T. K. M., & Yeung, Y. Y. (2005). Total synthesis of (-)-samaderine Y from (S)-(+)-carvone. Angewandte Chemie - International Edition, 44(48), 7981-7984. https://doi.org/10.1002/anie.200502763

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Access to Document

10.1002/anie.200502763