Abstract
(Chemical Equation Presented) Elegant, efficient, and enantiospecific describe the first total synthesis of the quassinoid (-)-samaderine Y (see scheme), which has been shown to display in vitro cytotoxicity and is of interest as a potential antitumor agent. Its synthesis has been accomplished from (S)-(+)-carvone in 21 steps.
Original language | English |
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Pages (from-to) | 7981-7984 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 44 |
Issue number | 48 |
DOIs | |
Publication status | Published - 2005 Dec 9 |
Keywords
- Antitumor agents
- Fused-ring systems
- Natural products
- Quassinoids
- Total synthesis
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)