Total synthesis of (-)-samaderine Y from (S)-(+)-carvone

Tony Kung Ming Shing, Ying Y. Yeung

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

(Chemical Equation Presented) Elegant, efficient, and enantiospecific describe the first total synthesis of the quassinoid (-)-samaderine Y (see scheme), which has been shown to display in vitro cytotoxicity and is of interest as a potential antitumor agent. Its synthesis has been accomplished from (S)-(+)-carvone in 21 steps.

Original languageEnglish
Pages (from-to)7981-7984
Number of pages4
JournalAngewandte Chemie - International Edition
Volume44
Issue number48
DOIs
Publication statusPublished - 2005 Dec 9
Externally publishedYes

Fingerprint

Quassins
Cytotoxicity
Antineoplastic Agents
carvone
samaderine Y

Keywords

  • Antitumor agents
  • Fused-ring systems
  • Natural products
  • Quassinoids
  • Total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Total synthesis of (-)-samaderine Y from (S)-(+)-carvone. / Shing, Tony Kung Ming; Yeung, Ying Y.

In: Angewandte Chemie - International Edition, Vol. 44, No. 48, 09.12.2005, p. 7981-7984.

Research output: Contribution to journalArticle

Shing, Tony Kung Ming ; Yeung, Ying Y. / Total synthesis of (-)-samaderine Y from (S)-(+)-carvone. In: Angewandte Chemie - International Edition. 2005 ; Vol. 44, No. 48. pp. 7981-7984.
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