Total synthesis of (-)-samaderine Y from (S)-(+)-carvone

Tony K.M. Shing, Ying Y. Yeung

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

(Chemical Equation Presented) Elegant, efficient, and enantiospecific describe the first total synthesis of the quassinoid (-)-samaderine Y (see scheme), which has been shown to display in vitro cytotoxicity and is of interest as a potential antitumor agent. Its synthesis has been accomplished from (S)-(+)-carvone in 21 steps.

Original languageEnglish
Pages (from-to)7981-7984
Number of pages4
JournalAngewandte Chemie - International Edition
Volume44
Issue number48
DOIs
Publication statusPublished - 2005 Dec 9

Keywords

  • Antitumor agents
  • Fused-ring systems
  • Natural products
  • Quassinoids
  • Total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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