Total synthesis of siomycin A

Tomonori Mori, Shuhei Higashibayashi, Taiji Goto, Mitsunori Kohno, Yukiko Satouchi, Kazuyuki Shinko, Kengo Suzuki, Shunya Suzuki, Hiraku Tohmiya, Kimiko Hashimoto, Masaya Nakata

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We have succeeded in the total synthesis of siomycin A, a representative compound of the thiostrepton family of peptide antibiotics, featuring the one-pot cyclization-elongation of our strategic intermediates and the late-stage formations of the thiazoline and dehydroamino acid moieties.

Original languageEnglish
Pages (from-to)1331-1335
Number of pages5
JournalTetrahedron Letters
Volume48
Issue number8
DOIs
Publication statusPublished - 2007 Feb 19

Fingerprint

Thiostrepton
Cyclization
Elongation
Anti-Bacterial Agents
Peptides
Acids
siomycin A

Keywords

  • Dehydroamino acid
  • One-pot cyclization-elongation
  • Siomycin A
  • Thiazoline

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Mori, T., Higashibayashi, S., Goto, T., Kohno, M., Satouchi, Y., Shinko, K., ... Nakata, M. (2007). Total synthesis of siomycin A. Tetrahedron Letters, 48(8), 1331-1335. https://doi.org/10.1016/j.tetlet.2006.12.121

Total synthesis of siomycin A. / Mori, Tomonori; Higashibayashi, Shuhei; Goto, Taiji; Kohno, Mitsunori; Satouchi, Yukiko; Shinko, Kazuyuki; Suzuki, Kengo; Suzuki, Shunya; Tohmiya, Hiraku; Hashimoto, Kimiko; Nakata, Masaya.

In: Tetrahedron Letters, Vol. 48, No. 8, 19.02.2007, p. 1331-1335.

Research output: Contribution to journalArticle

Mori, T, Higashibayashi, S, Goto, T, Kohno, M, Satouchi, Y, Shinko, K, Suzuki, K, Suzuki, S, Tohmiya, H, Hashimoto, K & Nakata, M 2007, 'Total synthesis of siomycin A', Tetrahedron Letters, vol. 48, no. 8, pp. 1331-1335. https://doi.org/10.1016/j.tetlet.2006.12.121
Mori T, Higashibayashi S, Goto T, Kohno M, Satouchi Y, Shinko K et al. Total synthesis of siomycin A. Tetrahedron Letters. 2007 Feb 19;48(8):1331-1335. https://doi.org/10.1016/j.tetlet.2006.12.121
Mori, Tomonori ; Higashibayashi, Shuhei ; Goto, Taiji ; Kohno, Mitsunori ; Satouchi, Yukiko ; Shinko, Kazuyuki ; Suzuki, Kengo ; Suzuki, Shunya ; Tohmiya, Hiraku ; Hashimoto, Kimiko ; Nakata, Masaya. / Total synthesis of siomycin A. In: Tetrahedron Letters. 2007 ; Vol. 48, No. 8. pp. 1331-1335.
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AU - Tohmiya, Hiraku

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