Total synthesis of siomycin A

Tomonori Mori, Shuhei Higashibayashi, Taiji Goto, Mitsunori Kohno, Yukiko Satouchi, Kazuyuki Shinko, Kengo Suzuki, Shunya Suzuki, Hiraku Tohmiya, Kimiko Hashimoto, Masaya Nakata

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We have succeeded in the total synthesis of siomycin A, a representative compound of the thiostrepton family of peptide antibiotics, featuring the one-pot cyclization-elongation of our strategic intermediates and the late-stage formations of the thiazoline and dehydroamino acid moieties.

Original languageEnglish
Pages (from-to)1331-1335
Number of pages5
JournalTetrahedron Letters
Volume48
Issue number8
DOIs
Publication statusPublished - 2007 Feb 19

Keywords

  • Dehydroamino acid
  • One-pot cyclization-elongation
  • Siomycin A
  • Thiazoline

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Mori, T., Higashibayashi, S., Goto, T., Kohno, M., Satouchi, Y., Shinko, K., Suzuki, K., Suzuki, S., Tohmiya, H., Hashimoto, K., & Nakata, M. (2007). Total synthesis of siomycin A. Tetrahedron Letters, 48(8), 1331-1335. https://doi.org/10.1016/j.tetlet.2006.12.121