Total synthesis of spicamycin amino nucleoside

Tamotsu Suzuki, Sayaka Tanaka, Iwao Yamada, Yoshiaki Koashi, Kazue Yamada, Noritaka Chida

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The first total synthesis of spicamycin amino nucleoside 2 has been achieved. The aminoheptose unit 5 was prepared stereoselectively from myo-inositol, and the characteristic N-glycoside linkage was constructed by way of Pd-catalyzed coupling reaction of 5 with 6-chloropurine derivative 6.

Original languageEnglish
Pages (from-to)1137-1140
Number of pages4
JournalOrganic Letters
Volume2
Issue number8
Publication statusPublished - 2000 Apr 20

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inositols
glucosides
nucleosides
Inositol
Glycosides
Nucleosides
linkages
Derivatives
synthesis
6-chloropurine
septacidin

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Suzuki, T., Tanaka, S., Yamada, I., Koashi, Y., Yamada, K., & Chida, N. (2000). Total synthesis of spicamycin amino nucleoside. Organic Letters, 2(8), 1137-1140.

Total synthesis of spicamycin amino nucleoside. / Suzuki, Tamotsu; Tanaka, Sayaka; Yamada, Iwao; Koashi, Yoshiaki; Yamada, Kazue; Chida, Noritaka.

In: Organic Letters, Vol. 2, No. 8, 20.04.2000, p. 1137-1140.

Research output: Contribution to journalArticle

Suzuki, T, Tanaka, S, Yamada, I, Koashi, Y, Yamada, K & Chida, N 2000, 'Total synthesis of spicamycin amino nucleoside', Organic Letters, vol. 2, no. 8, pp. 1137-1140.
Suzuki T, Tanaka S, Yamada I, Koashi Y, Yamada K, Chida N. Total synthesis of spicamycin amino nucleoside. Organic Letters. 2000 Apr 20;2(8):1137-1140.
Suzuki, Tamotsu ; Tanaka, Sayaka ; Yamada, Iwao ; Koashi, Yoshiaki ; Yamada, Kazue ; Chida, Noritaka. / Total synthesis of spicamycin amino nucleoside. In: Organic Letters. 2000 ; Vol. 2, No. 8. pp. 1137-1140.
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