TY - JOUR
T1 - Total synthesis of the trisaccharide of olivomycin A
AU - Toshima, Kazunobu
AU - Nozaki, Yuko
AU - Nakata, Masaya
AU - Tatsuta, Kuniaki
AU - Kinoshita, Mitsuhiro
N1 - Funding Information:
Acknowledgment. We are grateful to the Instituteo f Microbial Chemistry for the generouss upporto f our program.F inancial supportb y the Ministry of Education,S cience and Culture (Grant-in-Aid for Scientific Research) and Kawakami Memorial Foundationa re.g ratefullya cknowledged.
PY - 1993/9/3
Y1 - 1993/9/3
N2 - The total synthesis of the trisaccharide of olivomycin A, which is one of the aureolic acid antitumor antibiotics, has been achieved. Our approach involves highly stereocontrolled glycosidations using 2,6-ahnydro-2-thio glycosyl donors. The 2,6-anhydro-2-thio trisaccharide 21 was constructed from 4 and 5, and then converted into the 2,6-dideoxy trisaccharide of olivomycin A 3 by hydrogenolysis and deprotection.
AB - The total synthesis of the trisaccharide of olivomycin A, which is one of the aureolic acid antitumor antibiotics, has been achieved. Our approach involves highly stereocontrolled glycosidations using 2,6-ahnydro-2-thio glycosyl donors. The 2,6-anhydro-2-thio trisaccharide 21 was constructed from 4 and 5, and then converted into the 2,6-dideoxy trisaccharide of olivomycin A 3 by hydrogenolysis and deprotection.
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U2 - 10.1016/S0040-4039(00)73854-8
DO - 10.1016/S0040-4039(00)73854-8
M3 - Article
AN - SCOPUS:0027216696
SN - 0040-4039
VL - 34
SP - 5761
EP - 5764
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 36
ER -