Abstract
Luminamicin (1) was found to exhibit selective antibacterial activity against anaerobic bacteria by our group in 1985. The concise structure of 14-membered lactone of 1 was synthesized. Construction of a versatile enol ether moiety was achieved by Stille cross coupling via hydrostanylation of the ethynyl ether, and a maleic anhydride moiety was derived from the furan constitution by the oxidation after the macrolactonization at a late-stage.
Original language | English |
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Pages (from-to) | 2813-2816 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 53 |
Issue number | 23 |
DOIs | |
Publication status | Published - 2012 Jun 6 |
Externally published | Yes |
Keywords
- 14-Membered macrolactone
- Antianaerobic activity
- Coloradocin
- Conjugated enol ether
- Luminamicin
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry