Towards further optimization of preimplantation embryo culture media: From the viewpoint of Omics and Somatic Cell Nuclear Transfer (SCNT) studies

Research output: Contribution to journalArticle

Abstract

Assisted reproductive technology (ART) has greatly benefited numerous infertile couples who would never have had their babies without this technique. However, in vitro culture is reported to cause epigenetic and transcriptomic changes on preimplantation embryos, leading to adverse effect on development, and little is known about the molecular mechanisms underlying these changes. Here, we first introduce key studies that designate the effectiveness of an omic strategy to explore the molecular mechanisms governing preimplantation development of in vitro-cultured embryos. Furthermore, we review how in vitro culture components facilitate genomic reprogramming and zygotic genome activation (ZGA) contributing to preimplantation development after somatic cell nuclear transfer (SCNT). From these different perspectives, we would search for a breakthrough to further optimize preimplantation embryo culture conditions and improve ART.

Original languageEnglish
Pages (from-to)35-43
Number of pages9
JournalJournal of Mammalian Ova Research
Volume33
Issue number1
DOIs
Publication statusPublished - 2016 Apr 1

Keywords

  • Metabolomics
  • Octanoate
  • Preimplantation embryo
  • SCNT
  • ZGA

ASJC Scopus subject areas

  • Reproductive Medicine
  • Cell Biology

Fingerprint Dive into the research topics of 'Towards further optimization of preimplantation embryo culture media: From the viewpoint of Omics and Somatic Cell Nuclear Transfer (SCNT) studies'. Together they form a unique fingerprint.

  • Cite this