Towards the chemoenzymatic synthesis of lipid A

Takeshi Sugai, Helena Ritzén, Chi Huey Wong

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

New procedures have been developed for the synthesis of the two important components of lipid A; one is the lipase-catalyzed resolution of 3-hydroxyteradecanoic acid in tetrahydrofuran using vinyl acetate and the other is the synthesis of the disaccharide moiety using glycosylphosphite as the glycosylating reagenL.

Original languageEnglish
Pages (from-to)1051-1058
Number of pages8
JournalTetrahedron: Asymmetry
Volume4
Issue number5
DOIs
Publication statusPublished - 1993
Externally publishedYes

Fingerprint

Lipid A
Disaccharides
Lipase
Lipids
lipids
Acids
Lipases
synthesis
tetrahydrofuran
acetates
acids
vinyl acetate

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

Cite this

Towards the chemoenzymatic synthesis of lipid A. / Sugai, Takeshi; Ritzén, Helena; Wong, Chi Huey.

In: Tetrahedron: Asymmetry, Vol. 4, No. 5, 1993, p. 1051-1058.

Research output: Contribution to journalArticle

Sugai, Takeshi ; Ritzén, Helena ; Wong, Chi Huey. / Towards the chemoenzymatic synthesis of lipid A. In: Tetrahedron: Asymmetry. 1993 ; Vol. 4, No. 5. pp. 1051-1058.
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