Toxicity of intraperitoneally administrated silicon tetraalkoxides in male ICR mice.

H. Nakashima, K. Omae, K. Yamazaki, T. Sakai, H. Sakurai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The toxicities of silicon tetraalkoxides, including tetramethoxysilane [Si(OCH3)4, TMOS], tetraethoxysilane [Si(OC2H5)4, TEOS], tetrapropoxysilane [Si(OC3H7)4, TPOS] and tetrabuthoxysilane [Si(OC4H9)4, TBOS], were investigated with intraperitoneal injection of 1,000 mg/kg of each compound. TMOS, as well as TEOS, caused acute tubular necrosis. Blood biochemical examination revealed elevation of blood urea nitrogen and creatinine in mice treated with TEOS, TPOS and TBOS, though TMOS treated mice died and therefore could not be examined. The severity of nephrotoxicity differs among these silicon tetraalkoxides. The spleens of mice treated with TMOS exhibited cytolysis in the white and red pulp, suggesting direct injury to the spleen. The kidney seems to be a common target organ of silicon tetraalkoxides.

Original languageEnglish
Pages (from-to)122-124
Number of pages3
JournalKeio Journal of Medicine
Volume42
Issue number3
Publication statusPublished - 1993 Sep

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Inbred ICR Mouse
Silicon
Spleen
Blood Urea Nitrogen
Intraperitoneal Injections
Creatinine
Necrosis
Kidney
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nakashima, H., Omae, K., Yamazaki, K., Sakai, T., & Sakurai, H. (1993). Toxicity of intraperitoneally administrated silicon tetraalkoxides in male ICR mice. Keio Journal of Medicine, 42(3), 122-124.

Toxicity of intraperitoneally administrated silicon tetraalkoxides in male ICR mice. / Nakashima, H.; Omae, K.; Yamazaki, K.; Sakai, T.; Sakurai, H.

In: Keio Journal of Medicine, Vol. 42, No. 3, 09.1993, p. 122-124.

Research output: Contribution to journalArticle

Nakashima, H, Omae, K, Yamazaki, K, Sakai, T & Sakurai, H 1993, 'Toxicity of intraperitoneally administrated silicon tetraalkoxides in male ICR mice.', Keio Journal of Medicine, vol. 42, no. 3, pp. 122-124.
Nakashima H, Omae K, Yamazaki K, Sakai T, Sakurai H. Toxicity of intraperitoneally administrated silicon tetraalkoxides in male ICR mice. Keio Journal of Medicine. 1993 Sep;42(3):122-124.
Nakashima, H. ; Omae, K. ; Yamazaki, K. ; Sakai, T. ; Sakurai, H. / Toxicity of intraperitoneally administrated silicon tetraalkoxides in male ICR mice. In: Keio Journal of Medicine. 1993 ; Vol. 42, No. 3. pp. 122-124.
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