Toxicity of Intraperitoneally Administrated Silicon Tetraalkoxides in Male ICR Mice

Hiroshi Nakashima; Kazuyuki Omae; Tohru Sakai; Haruhiko Sakurai; Kazuto Yamazaki

doi:10.2302/kjm.42.122

Toxicity of Intraperitoneally Administrated Silicon Tetraalkoxides in Male ICR Mice

Hiroshi Nakashima, Kazuyuki Omae, Tohru Sakai, Haruhiko Sakurai, Kazuto Yamazaki

Department of Preventive Medicine and Public Health

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

The toxicities of silicon tetraalkoxides, including tetramethoxysilane [Si(OCH₃)₄, TMOS], tetraethoxysilane [Si(OC₂H₅)₄, TEOS], tetrapropoxysilane [Si(OC₃H₇)₄, TPOS] and tetrabuthoxysilane [Si(OC₄H₉)₄, TBOS], were investigated with intraperitoneal injection of 1, 000 mg/kg of each compound. TMOS, as well as TEOS, caused acute tubular necrosis. Blood biochemical examination revealed elevation of blood urea nitrogen and creatinine in mice treated with TEOS, TPOS and TBOS, though TMOS treated mice died and therefore could not be examined. The severity of nephrotoxicity differs among these silicon tetraalkoxides. The spleens of mice treated with TMOS exhibited cytolysis in the white and red pulp, suggesting direct injury to the spleen. The kidney seems to be a common target, organ of silicon tetraalkoxides.

Original language	English
Pages (from-to)	122-124
Number of pages	3
Journal	the keio journal of medicine
Volume	42
Issue number	3
DOIs	https://doi.org/10.2302/kjm.42.122
Publication status	Published - 1993 Jan 1

Keywords

nephrotoxicity
semiconductor
tetraethoxysilane
tetramethoxysilane

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.2302/kjm.42.122

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Nakashima, H., Omae, K., Sakai, T., Sakurai, H., & Yamazaki, K. (1993). Toxicity of Intraperitoneally Administrated Silicon Tetraalkoxides in Male ICR Mice. the keio journal of medicine, 42(3), 122-124. https://doi.org/10.2302/kjm.42.122

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title = "Toxicity of Intraperitoneally Administrated Silicon Tetraalkoxides in Male ICR Mice",

abstract = "The toxicities of silicon tetraalkoxides, including tetramethoxysilane [Si(OCH3)4, TMOS], tetraethoxysilane [Si(OC2H5)4, TEOS], tetrapropoxysilane [Si(OC3H7)4, TPOS] and tetrabuthoxysilane [Si(OC4H9)4, TBOS], were investigated with intraperitoneal injection of 1, 000 mg/kg of each compound. TMOS, as well as TEOS, caused acute tubular necrosis. Blood biochemical examination revealed elevation of blood urea nitrogen and creatinine in mice treated with TEOS, TPOS and TBOS, though TMOS treated mice died and therefore could not be examined. The severity of nephrotoxicity differs among these silicon tetraalkoxides. The spleens of mice treated with TMOS exhibited cytolysis in the white and red pulp, suggesting direct injury to the spleen. The kidney seems to be a common target, organ of silicon tetraalkoxides.",

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author = "Hiroshi Nakashima and Kazuyuki Omae and Tohru Sakai and Haruhiko Sakurai and Kazuto Yamazaki",

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AU - Sakai, Tohru

AU - Sakurai, Haruhiko

AU - Yamazaki, Kazuto

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N2 - The toxicities of silicon tetraalkoxides, including tetramethoxysilane [Si(OCH3)4, TMOS], tetraethoxysilane [Si(OC2H5)4, TEOS], tetrapropoxysilane [Si(OC3H7)4, TPOS] and tetrabuthoxysilane [Si(OC4H9)4, TBOS], were investigated with intraperitoneal injection of 1, 000 mg/kg of each compound. TMOS, as well as TEOS, caused acute tubular necrosis. Blood biochemical examination revealed elevation of blood urea nitrogen and creatinine in mice treated with TEOS, TPOS and TBOS, though TMOS treated mice died and therefore could not be examined. The severity of nephrotoxicity differs among these silicon tetraalkoxides. The spleens of mice treated with TMOS exhibited cytolysis in the white and red pulp, suggesting direct injury to the spleen. The kidney seems to be a common target, organ of silicon tetraalkoxides.

AB - The toxicities of silicon tetraalkoxides, including tetramethoxysilane [Si(OCH3)4, TMOS], tetraethoxysilane [Si(OC2H5)4, TEOS], tetrapropoxysilane [Si(OC3H7)4, TPOS] and tetrabuthoxysilane [Si(OC4H9)4, TBOS], were investigated with intraperitoneal injection of 1, 000 mg/kg of each compound. TMOS, as well as TEOS, caused acute tubular necrosis. Blood biochemical examination revealed elevation of blood urea nitrogen and creatinine in mice treated with TEOS, TPOS and TBOS, though TMOS treated mice died and therefore could not be examined. The severity of nephrotoxicity differs among these silicon tetraalkoxides. The spleens of mice treated with TMOS exhibited cytolysis in the white and red pulp, suggesting direct injury to the spleen. The kidney seems to be a common target, organ of silicon tetraalkoxides.

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