Trabeculectomy with mitomycin C for post-keratoplasty glaucoma

Misaki Ishioka, Jun Shimazaki, Junkichi Yamagami, Hiroshi Fujishima, Shigeto Shimmura, Kazuo Tsubota

Research output: Contribution to journalArticle

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Abstract

Aim - To investigate the effect of trabeculectomy with and without mitomycin C in post-keratoplasty glaucoma. Methods - A retrospective study was performed on patients who underwent trabeculectomy for glaucoma after penetrating keratoplasty. 34 eyes of 32 patients were included in this study. 26 eyes received trabeculectomy with mitomycin C and eight eyes without mitomycin C. The procedure was deemed successful if the intraocular pressure was maintained below 21 mmHg with or without use of additional antiglaucoma medication (mean follow up time 22.3 (SD 10.3) months). Results - At the last examination trabeculectomy was successful in 19 of 26 eyes (73.0%) with mitomycin C (+) and two of eight (25.0%) without (p = 0.0219). When the prognosis was analysed by Kaplan-Meier curve, the mitomycin C (+) group showed a better prognosis (p = 0.0182). Mean intraocular pressure and average number of glaucoma medications improved in the group with mitomycin C without severe side effects on the graft. Graft rejection after trabeculectomy was seen in two eyes in the mitomycin C group. Final graft clarity rate was 69.2% (18/26) in the mitomycin C (+) group and 37.5% (3/8) in the mitomycin C (-) group. Complications such as persistent epithelial defect, cystoid macular oedema, choroidal detachment, leakage from bleb were seen in four eyes in the mitomycin C (+) group and in one eye in the mitomycin C (-) group. Conclusions - Trabeculectomy with mitomycin C showed better results for glaucoma following keratoplasty.

Original languageEnglish
Pages (from-to)714-717
Number of pages4
JournalBritish Journal of Ophthalmology
Volume84
Issue number7
DOIs
Publication statusPublished - 2000
Externally publishedYes

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Trabeculectomy
Corneal Transplantation
Mitomycin
Glaucoma
Intraocular Pressure
Transplants
Penetrating Keratoplasty
Macular Edema
Graft Rejection
Blister
Retrospective Studies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Trabeculectomy with mitomycin C for post-keratoplasty glaucoma. / Ishioka, Misaki; Shimazaki, Jun; Yamagami, Junkichi; Fujishima, Hiroshi; Shimmura, Shigeto; Tsubota, Kazuo.

In: British Journal of Ophthalmology, Vol. 84, No. 7, 2000, p. 714-717.

Research output: Contribution to journalArticle

Ishioka, Misaki ; Shimazaki, Jun ; Yamagami, Junkichi ; Fujishima, Hiroshi ; Shimmura, Shigeto ; Tsubota, Kazuo. / Trabeculectomy with mitomycin C for post-keratoplasty glaucoma. In: British Journal of Ophthalmology. 2000 ; Vol. 84, No. 7. pp. 714-717.
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abstract = "Aim - To investigate the effect of trabeculectomy with and without mitomycin C in post-keratoplasty glaucoma. Methods - A retrospective study was performed on patients who underwent trabeculectomy for glaucoma after penetrating keratoplasty. 34 eyes of 32 patients were included in this study. 26 eyes received trabeculectomy with mitomycin C and eight eyes without mitomycin C. The procedure was deemed successful if the intraocular pressure was maintained below 21 mmHg with or without use of additional antiglaucoma medication (mean follow up time 22.3 (SD 10.3) months). Results - At the last examination trabeculectomy was successful in 19 of 26 eyes (73.0{\%}) with mitomycin C (+) and two of eight (25.0{\%}) without (p = 0.0219). When the prognosis was analysed by Kaplan-Meier curve, the mitomycin C (+) group showed a better prognosis (p = 0.0182). Mean intraocular pressure and average number of glaucoma medications improved in the group with mitomycin C without severe side effects on the graft. Graft rejection after trabeculectomy was seen in two eyes in the mitomycin C group. Final graft clarity rate was 69.2{\%} (18/26) in the mitomycin C (+) group and 37.5{\%} (3/8) in the mitomycin C (-) group. Complications such as persistent epithelial defect, cystoid macular oedema, choroidal detachment, leakage from bleb were seen in four eyes in the mitomycin C (+) group and in one eye in the mitomycin C (-) group. Conclusions - Trabeculectomy with mitomycin C showed better results for glaucoma following keratoplasty.",
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