Traction Bronchiectasis/Bronchiolectasis is Associated with Interstitial Lung Abnormality Mortality

Tomoyuki Hida, Mizuki Nishino, Takuya Hino, Junwei Lu, Rachel K. Putman, Elias F. Gudmundsson, Tetsuro Araki, Vladimir I. Valtchinov, Osamu Honda, Masahiro Yanagawa, Yoshitake Yamada, Akinori Hata, Masahiro Jinzaki, Noriyuki Tomiyama, Hiroshi Honda, Raul San Jose Estepar, George R. Washko, Takeshi Johkoh, David C. Christiani, David A. LynchVilmundur Gudnason, Gunnar Gudmundsson, Gary M. Hunninghake, Hiroto Hatabu

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate if the presence and severity of traction bronchiectasis/bronchiolectasis are associated with poorer survival in subjects with ILA. Method: The study included 3,594 subjects (378 subjects with ILA and 3,216 subjects without ILA) in AGES-Reykjavik Study. Chest CT scans of 378 subjects with ILA were evaluated for traction bronchiectasis/bronchiolectasis, defined as dilatation of bronchi/bronchioles within areas demonstrating ILA. Traction bronchiectasis/bronchiolectasis Index (TBI) was assigned as: TBI = 0, ILA without traction bronchiectasis/bronchiolectasis: TBI = 1, ILA with bronchiolectasis but without bronchiectasis or architectural distortion: TBI = 2, ILA with mild to moderate traction bronchiectasis: TBI = 3, ILA and severe traction bronchiectasis and/or honeycombing. Overall survival (OS) was compared among the subjects in different TBI groups and those without ILA. Results: The median OS was 12.93 years (95%CI; 12.67 – 13.43) in the subjects without ILA; 11.95 years (10.03 – not reached) in TBI-0 group; 8.52 years (7.57 – 9.30) in TBI-1 group; 7.63 years (6.09 – 9.10) in TBI-2 group; 5.40 years (1.85 – 5.98) in TBI-3 group. The multivariable Cox models demonstrated significantly shorter OS of TBI-1, TBI-2, and TBI-3 groups compared to subjects without ILA (P < 0.0001), whereas TBI-0 group had no significant OS difference compared to subjects without ILA, after adjusting for age, sex, and smoking status. Conclusions: The presence and severity of traction bronchiectasis/bronchiolectasis are associated with shorter survival. The traction bronchiectasis/bronchiolectasis is an important contributor to increased mortality among subjects with ILA.

Original languageEnglish
Article number109073
JournalEuropean Journal of Radiology
Volume129
DOIs
Publication statusPublished - 2020 Aug

Keywords

  • Age Gene/Environment Susceptibility-Reykjavik Study
  • Interstitial lung abnormality
  • Pulmonary fibrosis
  • Traction bronchiectasis
  • Usual interstitial pneumonia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Hida, T., Nishino, M., Hino, T., Lu, J., Putman, R. K., Gudmundsson, E. F., Araki, T., Valtchinov, V. I., Honda, O., Yanagawa, M., Yamada, Y., Hata, A., Jinzaki, M., Tomiyama, N., Honda, H., Estepar, R. S. J., Washko, G. R., Johkoh, T., Christiani, D. C., ... Hatabu, H. (2020). Traction Bronchiectasis/Bronchiolectasis is Associated with Interstitial Lung Abnormality Mortality. European Journal of Radiology, 129, [109073]. https://doi.org/10.1016/j.ejrad.2020.109073