Tranilast inhibits the effects of platelet-derived growth factor on cell priliferation and induction of nitric oxide

Keiichi Hishikawa, Toshio Nakaki, Junichi Hirahashi, Takeshi Marumo, Takao Saruta

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The effects of tranilast on DNA synthesis and cell proliferation in cultured rat mesangial cells, treated with platelet-derived growth factor (PDGF), were investigated. Tranilast significantly inhibited PDGF-stimulated DNA synthesis and cell proliferation in a dose-dependent manner. In the absence of PDGF, it also enhanced cytokine-induced nitric oxide (NO) production. PDGF significantly inhibited cytokine-induced NO production, but tranilast completely abolished this inhibitory effect of PDGF. These results show that tranilast inhibits PDGF-induced proliferation of mesangial cells under both normal and inflammatory conditions.

Original languageEnglish
Pages (from-to)435-438
Number of pages4
JournalEuropean Journal of Pharmacology: Molecular Pharmacology
Volume291
Issue number3
DOIs
Publication statusPublished - 1995 Nov 30

Keywords

  • Mesangial cell
  • Nitric oxide (NO)
  • PDGF (platelet-derived growth factor)
  • Tranilast

ASJC Scopus subject areas

  • Pharmacology

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