@article{b1f6839fae58454a8af1d6001a9ac860,
title = "Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle",
abstract = "Systemic metabolic homeostasis is regulated by inter-organ metabolic cycles involving multiple organs. Obesity impairs inter-organ metabolic cycles, resulting in metabolic diseases. The systemic landscape of dysregulated inter-organ metabolic cycles in obesity has yet to be explored. Here, we measured the transcriptome, proteome, and metabolome in the liver and skeletal muscle and the metabolome in blood of fasted wild-type and leptin-deficient obese (ob/ob) mice, identifying components with differential abundance and differential regulation in ob/ob mice. By constructing and evaluating the trans-omic network controlling the differences in metabolic reactions between fasted wild-type and ob/ob mice, we provided potential mechanisms of the obesity-associated dysfunctions of metabolic cycles between liver and skeletal muscle involving glucose-alanine, glucose-lactate, and ketone bodies. Our study revealed obesity-associated systemic pathological mechanisms of dysfunction of inter-organ metabolic cycles.",
keywords = "Biological Sciences, Endocrinology, Metabolomics, Omics, Proteomics, Systems Biology, Transcriptomic",
author = "Riku Egami and Toshiya Kokaji and Atsushi Hatano and Katsuyuki Yugi and Miki Eto and Keigo Morita and Satoshi Ohno and Masashi Fujii and Hironaka, {Ken ichi} and Saori Uematsu and Akira Terakawa and Yunfan Bai and Yifei Pan and Takaho Tsuchiya and Haruka Ozaki and Hiroshi Inoue and Shinsuke Uda and Hiroyuki Kubota and Yutaka Suzuki and Masaki Matsumoto and Nakayama, {Keiichi I.} and Akiyoshi Hirayama and Tomoyoshi Soga and Shinya Kuroda",
note = "Funding Information: This work was supported by the Creation of Fundamental Technologies for Understanding and Control of Biosystem Dynamics, CREST ( JPMJCR12W3 ) from the Japan Science and Technology Agency (JST), by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number JP17H06300 , JP17H06299 , JP18H03979 , and by The Uehara Memorial Foundation. R.E. receives funding from JSPS KAKENHI Grant Number JP19J10234 . K.Y. receives funding from JSPS KAKENHI Grant Number JP15H05582 , JP18H05431 , and {\textquoteleft}{\textquoteleft}Creation of Innovative Technology for Medical Applications Based on the Global Analyses and Regulation of Disease-Related Metabolites{\textquoteright}{\textquoteright}, PRESTO ( JPMJPR1538 ) from JST . S.O. receives funding from a Grant-in-Aid for Young Scientists (B) ( JP17K14864 ). M.F. receives funding from JSPS KAKENHI Grant Number JP19K20382 and JP16K12508 . T.T. was supported by JSPS KAKENHI Grant Number JP19K24361 , JP20K19915 . H.O. was supported by JSPS KAKENHI Grant Number JP19H03696 , JP19K20394 . H. I. was supported by JSPS KAKENHI Grant Number JP18KT0020 , JP17H05499 , and by Adaptable and Seamless Technology transfer Program through Target-driven R&D (A-STEP) from JST. S.U. was supported by JSPS KAKENHI Grant Number JP18H02431 , JP20H04847 . H.K. was supported by JSPS KAKENHI Grant Number JP16H06577 . Y.S. was supported by the JSPS KAKENHI Grant Number JP17H06306 . K.I.N. was supported by the JSPS KAKENHI Grant Number JP17H06301 , JP18H05215 . A.H. was supported by the JSPS KAKENHI Grant Number JP18H04804 . T.S. receives funding from the AMED-CREST from the Japan Agency for Medical Research and Development (AMED) under Grant Number JP18gm0710003 . Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2021",
month = mar,
day = "19",
doi = "10.1016/j.isci.2021.102217",
language = "English",
volume = "24",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "3",
}
