Trans-pairing between osteoclasts and osteoblasts shapes the cranial base during development

Mio Edamoto, Yukiko Kuroda, Masaki Yoda, Katsuhiro Kawaai, Koichi Matsuo

Research output: Contribution to journalArticle

Abstract

Bone growth is linked to expansion of nearby organs, as is the case for the cranial base and the brain. Here, we focused on development of the mouse clivus, a sloping surface of the basioccipital bone, to define mechanisms underlying morphological changes in bone in response to brain enlargement. Histological analysis indicated that both endocranial and ectocranial cortical bone layers in the basioccipital carry the osteoclast surface dorsally and the osteoblast surface ventrally. Finite element analysis of mechanical stress on the clivus revealed that compressive and tensile stresses appeared mainly on respective dorsal and ventral surfaces of the basioccipital bone. Osteoclastic bone resorption occurred primarily in the compression area, whereas areas of bone formation largely coincided with the tension area. These data collectively suggest that compressive and tensile stresses govern respective localization of osteoclasts and osteoblasts. Developmental analysis of the basioccipital bone revealed the clivus to be angled in early postnatal wild-type mice, whereas its slope was less prominent in Tnfsf11 −/− mice, which lack osteoclasts. We propose that osteoclast-osteoblast “trans-pairing” across cortical bone is primarily induced by mechanical stress from growing organs and regulates shape and size of bones that encase the brain.

Original languageEnglish
Article number1956
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - 2019 Dec 1

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Skull Base
Osteoclasts
Osteoblasts
Posterior Cranial Fossa
Bone and Bones
Mechanical Stress
Brain
Finite Element Analysis
Bone Development
Bone Resorption
Osteogenesis
Cortical Bone

ASJC Scopus subject areas

  • General

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Trans-pairing between osteoclasts and osteoblasts shapes the cranial base during development. / Edamoto, Mio; Kuroda, Yukiko; Yoda, Masaki; Kawaai, Katsuhiro; Matsuo, Koichi.

In: Scientific Reports, Vol. 9, No. 1, 1956, 01.12.2019.

Research output: Contribution to journalArticle

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