Transcatheter hepatic arterial chemoembolization using epirubicin-lipiodol: experimental and pharmacological evaluation

Seiji Kobayashi, Yoshiaki Narimatsu, Kenji Ogawa, Subaru Hashimoto, Seishi Nakatsuka, Hiroshi Miura, Hirokuni Ohzono, Wei Jei Ka, Kunio Ido, Kyoichi Hiramatsu, Toshiharu Tsuzuki, Masaharu Tsuchiya

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Abstract

The experimental and pharmacological characteristics of various formulations of an anticancer agent (epirubicin, EPI) and lipiodol were evaluated in vitro and in vivo. Three forms of EPI-lipiodol, i.e., an oil-in-water type of emulsion (O/W type), a water-in-oil type of emulsion (W/O type), and a suspension (S type), were prepared and investigated for their stability. An O/W-type emulsion using a stock solution of Iopamidol as the solvent for EPI was the most stable form in the stationary state in vitro. In 16 patients with malignant liver tumors (14 hepatocellular carcinomas and 2 liver metastases), the three forms of EPI-lipiodol were injected into the proper hepatic artery. The plasma EPI level was monitored periodically and analyzed pharmacokinetically. No significant difference in the pharmacokinetics of EPI was detected among the O/W, W/O, and S types.

Original languageEnglish
Pages (from-to)S45-S50
JournalCancer Chemotherapy and Pharmacology
Volume31
Issue number1 Supplement
DOIs
Publication statusPublished - 1992 Jan 1

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ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

Cite this

Kobayashi, S., Narimatsu, Y., Ogawa, K., Hashimoto, S., Nakatsuka, S., Miura, H., Ohzono, H., Ka, W. J., Ido, K., Hiramatsu, K., Tsuzuki, T., & Tsuchiya, M. (1992). Transcatheter hepatic arterial chemoembolization using epirubicin-lipiodol: experimental and pharmacological evaluation. Cancer Chemotherapy and Pharmacology, 31(1 Supplement), S45-S50. https://doi.org/10.1007/BF00687104