Transcranial magnetic stimulation modulates resting EEG functional connectivity between the left dorsolateral prefrontal cortex and limbic regions in medicated patients with treatment-resistant depression

Shinsuke Kito, Takashi Hasegawa, Akihiro Takamiya, Takamasa Noda, Kazuyuki Nakagome, Teruhiko Higuchi, Yoshihiko Koga

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

High-frequency left prefrontal repetitive transcranial magnetic stimulation (rTMS) has been shown to have efficacy in treatment-resistant depression. However, the effects of rTMS on functional connectivity are still not clear. To examine changes in functional connectivity before and after rTMS, resting EEG of 14 patients with treatment-resistant depression was recorded twice at baseline and at week 4, respectively. The EEG data were analyzed using the standardized low-resolution brain electromagnetic tomography (sLORETA). The results reveal that high-frequency left prefrontal rTMS modulates resting EEG functional connectivity between the left dorsolateral prefrontal cortex and limbic regions, including the subgenual cingulate cortex and parahippocampal gyrus.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume29
Issue number2
DOIs
Publication statusPublished - 2017 Mar 1
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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