Transcription Factors and Epigenetic Modulation: Its Therapeutic Implication in Chronic Kidney Disease

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5 Citations (Scopus)

Abstract

Recently emerging evidence has shown that epigenetic mechanisms are involved in initiation and progression of various diseases, including kidney diseases. In the present article, we review the current data regarding the role of epigenetic modulation in chronic kidney disease (CKD) and kidney fibrosis, including DNA methylation and histone modification. Especially we focused on the role of transcription factors in epigenetic modulation and the possibility of therapeutic target of CKD. We have recently reported that transcription factor Kruppel-like factor 4 (also known as gut-enriched Kruppel-like factor) is expressed in kidney podocytes (visceral epithelial cells) and modulates podocyte phenotype by gene-selective epigenetic control. Targeting transcription factors for epigenetic modification may be a good candidate for remission and regression of CKD. It is necessary for the therapy of CKD with an epigenetic-based approach to investigate organ-, tissue-, or gene-specific treatment methods for reduction of side effects.

Original languageEnglish
JournalArchivum Immunologiae et Therapiae Experimentalis
DOIs
Publication statusAccepted/In press - 2014 Dec 11

Fingerprint

Chronic Renal Insufficiency
Epigenomics
Transcription Factors
Podocytes
Therapeutics
Histone Code
Kidney
Kidney Diseases
DNA Methylation
Genes
Disease Progression
Fibrosis
Epithelial Cells
Phenotype

Keywords

  • Chronic kidney disease
  • DNA methylation
  • Epigenetics
  • Histone modification
  • Transcription factors

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

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