Abstract
A transcutaneous blood glucose monitoring system consists of an ion-sensitive field-effect transistor (ISFET) glucose sensor unit and a suction effusion fluid (SEF) collecting unit. The SEF is directly collected by a weak suction (400 mmHg absolute pressure) through the skin from which the corneum layer of the epidermis has been previously removed. An ISFET glucose sensor unit is able to measure glucose concentrations in a microliter order sampling volume. The system was applied to three diabetic patients during a 75 g oral glucose tolerance test for monitoring blood glucose levels. During the experiments, glucose changes in the SEF followed actual blood glucose levels with 10 min delays. Results suggest the feasibility of utilizing quasi-continuous, transcutaneous blood glucose monitoring for individual patients with various diabetic histories or diabetic complications.
| Original language | English |
|---|---|
| Pages (from-to) | 269-280 |
| Number of pages | 12 |
| Journal | Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering |
| Volume | 6 |
| Issue number | 4 |
| Publication status | Published - 1995 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biophysics
Cite this
Transcutaneous blood glucose monitoring system based on an ISFET glucose sensor and studies on diabetic patients. / Ito, N.; Saito, A.; Kayashima, S.; Kimura, J.; Kuriyama, T.; Nagata, N.; Arai, Tsunenori; Kikuchi, M.
In: Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering, Vol. 6, No. 4, 1995, p. 269-280.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Transcutaneous blood glucose monitoring system based on an ISFET glucose sensor and studies on diabetic patients.
AU - Ito, N.
AU - Saito, A.
AU - Kayashima, S.
AU - Kimura, J.
AU - Kuriyama, T.
AU - Nagata, N.
AU - Arai, Tsunenori
AU - Kikuchi, M.
PY - 1995
Y1 - 1995
N2 - A transcutaneous blood glucose monitoring system consists of an ion-sensitive field-effect transistor (ISFET) glucose sensor unit and a suction effusion fluid (SEF) collecting unit. The SEF is directly collected by a weak suction (400 mmHg absolute pressure) through the skin from which the corneum layer of the epidermis has been previously removed. An ISFET glucose sensor unit is able to measure glucose concentrations in a microliter order sampling volume. The system was applied to three diabetic patients during a 75 g oral glucose tolerance test for monitoring blood glucose levels. During the experiments, glucose changes in the SEF followed actual blood glucose levels with 10 min delays. Results suggest the feasibility of utilizing quasi-continuous, transcutaneous blood glucose monitoring for individual patients with various diabetic histories or diabetic complications.
AB - A transcutaneous blood glucose monitoring system consists of an ion-sensitive field-effect transistor (ISFET) glucose sensor unit and a suction effusion fluid (SEF) collecting unit. The SEF is directly collected by a weak suction (400 mmHg absolute pressure) through the skin from which the corneum layer of the epidermis has been previously removed. An ISFET glucose sensor unit is able to measure glucose concentrations in a microliter order sampling volume. The system was applied to three diabetic patients during a 75 g oral glucose tolerance test for monitoring blood glucose levels. During the experiments, glucose changes in the SEF followed actual blood glucose levels with 10 min delays. Results suggest the feasibility of utilizing quasi-continuous, transcutaneous blood glucose monitoring for individual patients with various diabetic histories or diabetic complications.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029198318&partnerID=8YFLogxK
M3 - Article
C2 - 7612502
AN - SCOPUS:0029198318
VL - 6
SP - 269
EP - 280
JO - Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering
JF - Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering
SN - 0921-3775
IS - 4
ER -