Transformation into acute basophilic leukaemia in a patient with myelodysplastic syndrome

Tetsuya Yamagata, Akiyoshi Miwa, Mitsuoki Eguchi, Seiichi Kitagawa, Kazuo Muroi, Kiyohiko Hatake, Toshio Suda, Shinobu Sakamoto, Yasusada Miura

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8 Citations (Scopus)

Abstract

We describe a patient with basophilic leukaemia following a 2‐year period with myelodysplastic syndrome (refractory anaemia). The marrow showed 59.4% of blasts with 25.0% of mature and immature basophils. The leukaemic blasts contained granules, positively stained with toluidine blue but negative for peroxidase. The basophilic differentiation was confirmed by ultrastructural analysis demonstrating immature basophil granules. In addition, a morphological transition from immature blasts to more mature basophils was observed. Immunophenotypic analysis of blasts and basophils showed positive for CD5, CD7, CD13, CD33 and CD34. Cytogenetic investigation showed an abnormal karyotype, 46,XY,del(5)(q31q35). in 11% of the cells examined when the initial diagnosis of refractory anaemia was made. However, expansion of the same clone up to 100% was observed concomitantly with transformation to basophilic leukaemia.

Original languageEnglish
Pages (from-to)650-652
Number of pages3
JournalBritish Journal of Haematology
Volume89
Issue number3
DOIs
Publication statusPublished - 1995 Mar

Keywords

  • 5q‐
  • basophilic leukaemia
  • daunorubicin
  • myelodysplastic syndrome

ASJC Scopus subject areas

  • Hematology

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    Yamagata, T., Miwa, A., Eguchi, M., Kitagawa, S., Muroi, K., Hatake, K., Suda, T., Sakamoto, S., & Miura, Y. (1995). Transformation into acute basophilic leukaemia in a patient with myelodysplastic syndrome. British Journal of Haematology, 89(3), 650-652. https://doi.org/10.1111/j.1365-2141.1995.tb08381.x