Transformation into acute basophilic leukaemia in a patient with myelodysplastic syndrome

T. Yamagata, A. Miwa, M. Eguchi, S. Kitagawa, K. Muroi, K. Hatake, T. Suda, S. Sakamoto, Y. Miura

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We describe a patient with basophilic leukaemia following a 2-year period with myelodysplastic syndrome (refractory anaemia). The marrow showed 59.4% of blasts with 25.0% of mature and immature basophils. The leukaemic blasts contained granules, positively stained with toluidine blue but negative for peroxidase. The basophilic differentiation was confirmed by ultrastructural analysis demonstrating immature basophil granules. In addition, a morphological transition from immature blasts to more mature basophils was observed. Immunophenotypic analysis of blasts and basophils showed positive for CD5, CD7, CD13, CD33 and CD34. Cytogenetic investigation showed an abnormal karyotype, 46,XY,del(5)(q31q35), in 11% of the cells examined when the initial diagnosis of refractory anaemia was made. However, expansion of the same clone up to 100% was observed concomitantly with transformation to basophilic leukaemia.

Original languageEnglish
Pages (from-to)650-652
Number of pages3
JournalBritish Journal of Haematology
Volume89
Issue number3
Publication statusPublished - 1995

Fingerprint

Leukemia, Basophilic, Acute
Basophils
Myelodysplastic Syndromes
Refractory Anemia
Leukemia
Abnormal Karyotype
Tolonium Chloride
Cytogenetics
Peroxidase
Clone Cells
Bone Marrow

Keywords

  • 5q-
  • basophilic leukaemia
  • daunorubicin
  • myelodysplastic syndrome

ASJC Scopus subject areas

  • Hematology

Cite this

Yamagata, T., Miwa, A., Eguchi, M., Kitagawa, S., Muroi, K., Hatake, K., ... Miura, Y. (1995). Transformation into acute basophilic leukaemia in a patient with myelodysplastic syndrome. British Journal of Haematology, 89(3), 650-652.

Transformation into acute basophilic leukaemia in a patient with myelodysplastic syndrome. / Yamagata, T.; Miwa, A.; Eguchi, M.; Kitagawa, S.; Muroi, K.; Hatake, K.; Suda, T.; Sakamoto, S.; Miura, Y.

In: British Journal of Haematology, Vol. 89, No. 3, 1995, p. 650-652.

Research output: Contribution to journalArticle

Yamagata, T, Miwa, A, Eguchi, M, Kitagawa, S, Muroi, K, Hatake, K, Suda, T, Sakamoto, S & Miura, Y 1995, 'Transformation into acute basophilic leukaemia in a patient with myelodysplastic syndrome', British Journal of Haematology, vol. 89, no. 3, pp. 650-652.
Yamagata T, Miwa A, Eguchi M, Kitagawa S, Muroi K, Hatake K et al. Transformation into acute basophilic leukaemia in a patient with myelodysplastic syndrome. British Journal of Haematology. 1995;89(3):650-652.
Yamagata, T. ; Miwa, A. ; Eguchi, M. ; Kitagawa, S. ; Muroi, K. ; Hatake, K. ; Suda, T. ; Sakamoto, S. ; Miura, Y. / Transformation into acute basophilic leukaemia in a patient with myelodysplastic syndrome. In: British Journal of Haematology. 1995 ; Vol. 89, No. 3. pp. 650-652.
@article{8388590e07504133ae9d4a83fb9dfb75,
title = "Transformation into acute basophilic leukaemia in a patient with myelodysplastic syndrome",
abstract = "We describe a patient with basophilic leukaemia following a 2-year period with myelodysplastic syndrome (refractory anaemia). The marrow showed 59.4{\%} of blasts with 25.0{\%} of mature and immature basophils. The leukaemic blasts contained granules, positively stained with toluidine blue but negative for peroxidase. The basophilic differentiation was confirmed by ultrastructural analysis demonstrating immature basophil granules. In addition, a morphological transition from immature blasts to more mature basophils was observed. Immunophenotypic analysis of blasts and basophils showed positive for CD5, CD7, CD13, CD33 and CD34. Cytogenetic investigation showed an abnormal karyotype, 46,XY,del(5)(q31q35), in 11{\%} of the cells examined when the initial diagnosis of refractory anaemia was made. However, expansion of the same clone up to 100{\%} was observed concomitantly with transformation to basophilic leukaemia.",
keywords = "5q-, basophilic leukaemia, daunorubicin, myelodysplastic syndrome",
author = "T. Yamagata and A. Miwa and M. Eguchi and S. Kitagawa and K. Muroi and K. Hatake and T. Suda and S. Sakamoto and Y. Miura",
year = "1995",
language = "English",
volume = "89",
pages = "650--652",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Transformation into acute basophilic leukaemia in a patient with myelodysplastic syndrome

AU - Yamagata, T.

AU - Miwa, A.

AU - Eguchi, M.

AU - Kitagawa, S.

AU - Muroi, K.

AU - Hatake, K.

AU - Suda, T.

AU - Sakamoto, S.

AU - Miura, Y.

PY - 1995

Y1 - 1995

N2 - We describe a patient with basophilic leukaemia following a 2-year period with myelodysplastic syndrome (refractory anaemia). The marrow showed 59.4% of blasts with 25.0% of mature and immature basophils. The leukaemic blasts contained granules, positively stained with toluidine blue but negative for peroxidase. The basophilic differentiation was confirmed by ultrastructural analysis demonstrating immature basophil granules. In addition, a morphological transition from immature blasts to more mature basophils was observed. Immunophenotypic analysis of blasts and basophils showed positive for CD5, CD7, CD13, CD33 and CD34. Cytogenetic investigation showed an abnormal karyotype, 46,XY,del(5)(q31q35), in 11% of the cells examined when the initial diagnosis of refractory anaemia was made. However, expansion of the same clone up to 100% was observed concomitantly with transformation to basophilic leukaemia.

AB - We describe a patient with basophilic leukaemia following a 2-year period with myelodysplastic syndrome (refractory anaemia). The marrow showed 59.4% of blasts with 25.0% of mature and immature basophils. The leukaemic blasts contained granules, positively stained with toluidine blue but negative for peroxidase. The basophilic differentiation was confirmed by ultrastructural analysis demonstrating immature basophil granules. In addition, a morphological transition from immature blasts to more mature basophils was observed. Immunophenotypic analysis of blasts and basophils showed positive for CD5, CD7, CD13, CD33 and CD34. Cytogenetic investigation showed an abnormal karyotype, 46,XY,del(5)(q31q35), in 11% of the cells examined when the initial diagnosis of refractory anaemia was made. However, expansion of the same clone up to 100% was observed concomitantly with transformation to basophilic leukaemia.

KW - 5q-

KW - basophilic leukaemia

KW - daunorubicin

KW - myelodysplastic syndrome

UR - http://www.scopus.com/inward/record.url?scp=0028960458&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028960458&partnerID=8YFLogxK

M3 - Article

VL - 89

SP - 650

EP - 652

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 3

ER -