Transformation of keloids is determined by stress occurrence patterns on peri-keloid regions in response to body movement

Tomohisa Nagasao, Noriko Aramaki, Yusuke Shimizu, Sumiko Yoshitatsu, Naoki Takano, Kazuo Kishi

Research output: Contribution to journalArticle

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Abstract

Keloids gradually change their shapes as they grow. We hypothesize that the change of keloid morphology reflects the incremental change of the stress patterns occurring in peri-keloid regions due to movement of the keloid-carrying body part. To examine the validity of this hypothesis, we used three-dimensional finite element analysis to calculate the stresses occurring in the peri-keloid regions of keloids on the chest in response to respiratory movement. The stresses concentrate at the peri-keloid regions close to the bilateral ends of the keloids. By reviewing this result in reference to our hypothesis, we can explain why keloids on the chest are likely to present crab or butterfly shapes. Although we know that keloids grow in response to mechanical stresses, our hypothesis differs from existing ones in that it focuses on morphological transformation. Our hypothesis is helpful for physicians in performing treatment for keloids, because they can predict what part of a keloid is likely to grow and perform preventive treatment in reference to the hypothesis.

Original languageEnglish
Pages (from-to)136-141
Number of pages6
JournalMedical Hypotheses
Volume81
Issue number1
DOIs
Publication statusPublished - 2013 Jul

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Keloid
Thorax
Butterflies
Finite Element Analysis
Mechanical Stress
Human Body

ASJC Scopus subject areas

  • Medicine(all)

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Transformation of keloids is determined by stress occurrence patterns on peri-keloid regions in response to body movement. / Nagasao, Tomohisa; Aramaki, Noriko; Shimizu, Yusuke; Yoshitatsu, Sumiko; Takano, Naoki; Kishi, Kazuo.

In: Medical Hypotheses, Vol. 81, No. 1, 07.2013, p. 136-141.

Research output: Contribution to journalArticle

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