Transforming growth factor β2 autocrinally mediates neuronal cell death induced by amyloid-β

Yuichi Hashimoto, Mikiro Nawa, Tomohiro Chiba, Sadakazu Aiso, Ikuo Nishimoto, Masaaki Matsuoka

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Amyloid β (Aβ), the major component of the senile plaques of Alzheimer's disease, is implicated in neuronal cell death. We have found that Aβ42, a neurotoxic form of Aβ peptide, induces both neuronal and glial expression of TGFβ2. We have further demonstrated that the addition into culture media of neutralizing antibody to TGFβ2 or a large amount of the recombinant soluble amyloid precursor protein α, the extracellular domain of amyloid precursor protein (APP) generated by α secretase, suppresses death in primary cortical neurons (PCNs) induced by Aβ42 in vitro. Combined with the finding in our recent study indicating that TGFβ2 is a neuronal cell death-inducing ligand for APP, it is suggested that TGFβ2 is an autocrinal mediator for Aβ42-induced death in PCNs.

Original languageEnglish
Pages (from-to)1039-1047
Number of pages9
JournalJournal of neuroscience research
Volume83
Issue number6
DOIs
Publication statusPublished - 2006 May 1

Keywords

  • APP
  • Alzheimer's disease
  • TGFβ2

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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    Hashimoto, Y., Nawa, M., Chiba, T., Aiso, S., Nishimoto, I., & Matsuoka, M. (2006). Transforming growth factor β2 autocrinally mediates neuronal cell death induced by amyloid-β. Journal of neuroscience research, 83(6), 1039-1047. https://doi.org/10.1002/jnr.20804