Transgenic expression of FGF8 and FGF10 induces transdifferentiation of pancreatic islet cells into hepatocytes and exocrine cells

Takashi Yamaoka, Kenji Yoshino, Taketo Yamada, Makiko Yano, Takefumi Matsui, Takashi Yamaguchi, Maki Moritani, Jun Ichi Hata, Sumihare Noji, Mitsuo Itakura

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

FGF signaling is essential for normal development of pancreatic islets. To examine the effects of overexpressed FGF8 and FGF10 on pancreatic development, we generated FGF8- and FGF10-transgenic mice (Tg mice) under the control of the glucagon promoter. In FGF8-Tg mice, hepatocyte-like cells were observed in the periphery of pancreatic islets, but areas of α and β cells did not decrease, whereas in FGF10-Tg mice, pancreatic ductal and acinar cells were found in islets, concomitantly with disturbed β-cell differentiation. These results suggest that FGF8 and FGF10 play important roles in development of hepatocytes and exocrine cells, respectively, and explain the absence of FGF8 expression in normal islets and pancreatic hypoplasia in FGF10-deficient mice.

Original languageEnglish
Pages (from-to)138-143
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume292
Issue number1
DOIs
Publication statusPublished - 2002

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Islets of Langerhans
Hepatocytes
Transgenic Mice
Glucagon
Acinar Cells
Cell Differentiation

Keywords

  • Anophthalmia
  • Fibroblast growth factor 10
  • Fibroblast growth factor 8
  • Glucagon promoter
  • Hepatocyte
  • Pancreatic islet
  • Thyroid cancer
  • Transdifferentiation
  • Transgenic mice

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Transgenic expression of FGF8 and FGF10 induces transdifferentiation of pancreatic islet cells into hepatocytes and exocrine cells. / Yamaoka, Takashi; Yoshino, Kenji; Yamada, Taketo; Yano, Makiko; Matsui, Takefumi; Yamaguchi, Takashi; Moritani, Maki; Hata, Jun Ichi; Noji, Sumihare; Itakura, Mitsuo.

In: Biochemical and Biophysical Research Communications, Vol. 292, No. 1, 2002, p. 138-143.

Research output: Contribution to journalArticle

Yamaoka, T, Yoshino, K, Yamada, T, Yano, M, Matsui, T, Yamaguchi, T, Moritani, M, Hata, JI, Noji, S & Itakura, M 2002, 'Transgenic expression of FGF8 and FGF10 induces transdifferentiation of pancreatic islet cells into hepatocytes and exocrine cells', Biochemical and Biophysical Research Communications, vol. 292, no. 1, pp. 138-143. https://doi.org/10.1006/bbrc.2002.6601
Yamaoka, Takashi ; Yoshino, Kenji ; Yamada, Taketo ; Yano, Makiko ; Matsui, Takefumi ; Yamaguchi, Takashi ; Moritani, Maki ; Hata, Jun Ichi ; Noji, Sumihare ; Itakura, Mitsuo. / Transgenic expression of FGF8 and FGF10 induces transdifferentiation of pancreatic islet cells into hepatocytes and exocrine cells. In: Biochemical and Biophysical Research Communications. 2002 ; Vol. 292, No. 1. pp. 138-143.
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AU - Yano, Makiko

AU - Matsui, Takefumi

AU - Yamaguchi, Takashi

AU - Moritani, Maki

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AU - Noji, Sumihare

AU - Itakura, Mitsuo

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