Transgenic expression of FGF8 and FGF10 induces transdifferentiation of pancreatic islet cells into hepatocytes and exocrine cells

Takashi Yamaoka, Takefumi Matsui, Takashi Yamaguchi, Maki Moritani, Mitsuo Itakura, Kenji Yoshino, Makiko Yano, Taketo Yamada, Jun ichi Hata, Sumihare Noji

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

FGF signaling is essential for normal development of pancreatic islets. To examine the effects of overexpressed FGF8 and FGF10 on pancreatic development, we generated FGF8- and FGF10-transgenic mice (Tg mice) under the control of the glucagon promoter. In FGF8-Tg mice, hepatocyte-like cells were observed in the periphery of pancreatic islets, but areas of α and β cells did not decrease, whereas in FGF10-Tg mice, pancreatic ductal and acinar cells were found in islets, concomitantly with disturbed β-cell differentiation. These results suggest that FGF8 and FGF10 play important roles in development of hepatocytes and exocrine cells, respectively, and explain the absence of FGF8 expression in normal islets and pancreatic hypoplasia in FGF10-deficient mice.

Original languageEnglish
Pages (from-to)138-143
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume292
Issue number1
DOIs
Publication statusPublished - 2002

Keywords

  • Anophthalmia
  • Fibroblast growth factor 10
  • Fibroblast growth factor 8
  • Glucagon promoter
  • Hepatocyte
  • Pancreatic islet
  • Thyroid cancer
  • Transdifferentiation
  • Transgenic mice

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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