Transient hyper-17-OHPnemia unrelated to cross-reactions with residual fetal adrenal cortex products

Haruo Mizuno, Yoichiro Ohro, Yukari Sugiyama, Tetsuya Ito, Tomonobu Hasegawa, Keiko Homma, Hajime Ueshiba, Makoto Ono, Hajime Togari

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Objective: To clarify the pathogenesis of transient hyper-17α- hydroxyprogesteronemia, we initiated a laboratory investigation in a pre-term infant with persistently high serum 17α-hydroxyprogesterone (17-OHP) until 2 months of age. Methods: Serum 17-OHP level was measured by high-performance liquid chromatography and radioimmunoassay, and gene analysis of CYP21A2 (21-hydroxylase) was performed. Result: Serum 17-OHP level on the 29th day of life was 25.4 ng/ml, and the urinary steroid profile showed low pregnanetriolone. Gene analysis of 21-hydroxylase disclosed no mutation, and 17-OHP normalized by 3 months of age without specific treatment. Conclusion: Transient elevations in 17-OHP, which do not appear related to cross-reactions with products of a residual fetal adrenal cortex, may occur in the first few months of life.

Original languageEnglish
Pages (from-to)242-245
Number of pages4
JournalHormone Research
Volume61
Issue number5
DOIs
Publication statusPublished - 2004

Keywords

  • 21-Hydroxylase
  • Gas chromatography-mass spectrometry
  • High-performance liquid chromatography-radioimmunoassay
  • Hyper-17α-hydroxyprogesteronemia
  • Transient hyper-17-OHPnemia

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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