TY - JOUR
T1 - Transient hyper-17-OHPnemia unrelated to cross-reactions with residual fetal adrenal cortex products
AU - Mizuno, Haruo
AU - Ohro, Yoichiro
AU - Sugiyama, Yukari
AU - Ito, Tetsuya
AU - Hasegawa, Tomonobu
AU - Homma, Keiko
AU - Ueshiba, Hajime
AU - Ono, Makoto
AU - Togari, Hajime
PY - 2004
Y1 - 2004
N2 - Objective: To clarify the pathogenesis of transient hyper-17α- hydroxyprogesteronemia, we initiated a laboratory investigation in a pre-term infant with persistently high serum 17α-hydroxyprogesterone (17-OHP) until 2 months of age. Methods: Serum 17-OHP level was measured by high-performance liquid chromatography and radioimmunoassay, and gene analysis of CYP21A2 (21-hydroxylase) was performed. Result: Serum 17-OHP level on the 29th day of life was 25.4 ng/ml, and the urinary steroid profile showed low pregnanetriolone. Gene analysis of 21-hydroxylase disclosed no mutation, and 17-OHP normalized by 3 months of age without specific treatment. Conclusion: Transient elevations in 17-OHP, which do not appear related to cross-reactions with products of a residual fetal adrenal cortex, may occur in the first few months of life.
AB - Objective: To clarify the pathogenesis of transient hyper-17α- hydroxyprogesteronemia, we initiated a laboratory investigation in a pre-term infant with persistently high serum 17α-hydroxyprogesterone (17-OHP) until 2 months of age. Methods: Serum 17-OHP level was measured by high-performance liquid chromatography and radioimmunoassay, and gene analysis of CYP21A2 (21-hydroxylase) was performed. Result: Serum 17-OHP level on the 29th day of life was 25.4 ng/ml, and the urinary steroid profile showed low pregnanetriolone. Gene analysis of 21-hydroxylase disclosed no mutation, and 17-OHP normalized by 3 months of age without specific treatment. Conclusion: Transient elevations in 17-OHP, which do not appear related to cross-reactions with products of a residual fetal adrenal cortex, may occur in the first few months of life.
KW - 21-Hydroxylase
KW - Gas chromatography-mass spectrometry
KW - High-performance liquid chromatography-radioimmunoassay
KW - Hyper-17α-hydroxyprogesteronemia
KW - Transient hyper-17-OHPnemia
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U2 - 10.1159/000076961
DO - 10.1159/000076961
M3 - Article
C2 - 14988602
AN - SCOPUS:1842851860
SN - 1663-2818
VL - 61
SP - 242
EP - 245
JO - Steroids and lipids research
JF - Steroids and lipids research
IS - 5
ER -
