Transitional cell carcinoma of the upper urinary tract: Analysis of morphology and distribution for surgical management

Hiroyuki Fujimoto, Ken ichi Tobisu, Takashi Mizutani, Tadao Kakizoe, Michiie Sakamoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Two series of transitional cell carcinomas (TCC), one including 49 renal pelvic and/or ureteral cancers and the other 29 bladder cancers with concomitant ureteral involvement, were reviewed to establish the criteria for nephron-sparing surgery and for selecting the most appropriate surgical intervention for TCCs at the ureterovesical junction. The following categorization of tumors was made possible by histological mappings of step-sectioned surgical specimens from various surgical modes: 1) low grade papillary superficial tumor, 2) high grade papillary or non-papillary tumor with adjacent or skipped carcinoma in situ (CIS), 3) high grade non-papillary invasive tumor without CIS, 4) high grade papillary superficial tumor without CIS. We can, by comparing postoperative clinical courses, select the mode of surgery in the following manner: 1) nephronsparing surgery could be indicated in cases of low grade papillary tumor so far as a complete resection is possible; 2) in a case of high grade papillary or non-papillary tumor with adjacent or skipped CIS, extended resection of the urinary tract is required; 3) in a case of high grade non-pappillary tumor without CIS, complete en bloc resection of the tumor site, including surrounding organs, will be necessary. The possibility of organ-sparing surgery for early stage cancer without CIS at the ureterovesical junction has been suggested. Preoperative consideration of the above classifications for conservative surgery is also discussed.

Original languageEnglish
Pages (from-to)303-308
Number of pages6
JournalJapanese journal of clinical oncology
Volume23
Issue number5
DOIs
Publication statusPublished - 1993 Oct
Externally publishedYes

Keywords

  • Renal pelvis and ureter
  • Surgical management
  • Transitional cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Fingerprint Dive into the research topics of 'Transitional cell carcinoma of the upper urinary tract: Analysis of morphology and distribution for surgical management'. Together they form a unique fingerprint.

  • Cite this