Abstract
Apathy is a pervasive clinical phenomenon that deserves more attention at the translational and pre-clinical levels. To study apathy-like behavior in mice, we relied on an operational definition of apathy: the quantitative reduction of voluntary, goal-directed behaviors. We recently found that the chronic loss of function of a specific cell type (striatal dopamine receptor type 2-expressing medium spiny neurons, D2-MSN) in a restricted region (the ventrolateral striatum, VLS) was sufficient to induce apathy-like behavior in a food-seeking operant task. We further showed that VLS D2-MSN are activated at the preparatory period, and that optogenetic inhibition of VLS D2-MSN during that period resulted in transient decreases in instrumental motivation, strengthening the hypothesis that VLS D2-MSN mediate apathy-like behavior in mice. Mice bearing VLS D2-MSN dysfunction can thus be regarded as an apathy model for future translational studies.
| Original language | English |
|---|---|
| Journal | Psychiatry and Clinical Neurosciences |
| DOIs | |
| Publication status | Accepted/In press - 2019 Jan 1 |
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Keywords
- fiberphotometry
- goal-directed behavior
- motivation
- operant conditioning
- optogenetics
ASJC Scopus subject areas
- Neuroscience(all)
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
Cite this
Translational approach to apathy-like behavior in mice : From the practical point of view. / Tanaka, Kenji; Hamaguchi, Takuya.
In: Psychiatry and Clinical Neurosciences, 01.01.2019.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Translational approach to apathy-like behavior in mice
T2 - From the practical point of view
AU - Tanaka, Kenji
AU - Hamaguchi, Takuya
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Apathy is a pervasive clinical phenomenon that deserves more attention at the translational and pre-clinical levels. To study apathy-like behavior in mice, we relied on an operational definition of apathy: the quantitative reduction of voluntary, goal-directed behaviors. We recently found that the chronic loss of function of a specific cell type (striatal dopamine receptor type 2-expressing medium spiny neurons, D2-MSN) in a restricted region (the ventrolateral striatum, VLS) was sufficient to induce apathy-like behavior in a food-seeking operant task. We further showed that VLS D2-MSN are activated at the preparatory period, and that optogenetic inhibition of VLS D2-MSN during that period resulted in transient decreases in instrumental motivation, strengthening the hypothesis that VLS D2-MSN mediate apathy-like behavior in mice. Mice bearing VLS D2-MSN dysfunction can thus be regarded as an apathy model for future translational studies.
AB - Apathy is a pervasive clinical phenomenon that deserves more attention at the translational and pre-clinical levels. To study apathy-like behavior in mice, we relied on an operational definition of apathy: the quantitative reduction of voluntary, goal-directed behaviors. We recently found that the chronic loss of function of a specific cell type (striatal dopamine receptor type 2-expressing medium spiny neurons, D2-MSN) in a restricted region (the ventrolateral striatum, VLS) was sufficient to induce apathy-like behavior in a food-seeking operant task. We further showed that VLS D2-MSN are activated at the preparatory period, and that optogenetic inhibition of VLS D2-MSN during that period resulted in transient decreases in instrumental motivation, strengthening the hypothesis that VLS D2-MSN mediate apathy-like behavior in mice. Mice bearing VLS D2-MSN dysfunction can thus be regarded as an apathy model for future translational studies.
KW - fiberphotometry
KW - goal-directed behavior
KW - motivation
KW - operant conditioning
KW - optogenetics
UR - http://www.scopus.com/inward/record.url?scp=85071018581&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071018581&partnerID=8YFLogxK
U2 - 10.1111/pcn.12915
DO - 10.1111/pcn.12915
M3 - Review article
C2 - 31304614
AN - SCOPUS:85071018581
JO - Psychiatry and Clinical Neurosciences
JF - Psychiatry and Clinical Neurosciences
SN - 1323-1316
ER -