Translational approach to apathy-like behavior in mice: From the practical point of view

Kenji Tanaka, Takuya Hamaguchi

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Apathy is a pervasive clinical phenomenon that deserves more attention at the translational and pre-clinical levels. To study apathy-like behavior in mice, we relied on an operational definition of apathy: the quantitative reduction of voluntary, goal-directed behaviors. We recently found that the chronic loss of function of a specific cell type (striatal dopamine receptor type 2-expressing medium spiny neurons, D2-MSN) in a restricted region (the ventrolateral striatum, VLS) was sufficient to induce apathy-like behavior in a food-seeking operant task. We further showed that VLS D2-MSN are activated at the preparatory period, and that optogenetic inhibition of VLS D2-MSN during that period resulted in transient decreases in instrumental motivation, strengthening the hypothesis that VLS D2-MSN mediate apathy-like behavior in mice. Mice bearing VLS D2-MSN dysfunction can thus be regarded as an apathy model for future translational studies.

Original languageEnglish
JournalPsychiatry and Clinical Neurosciences
DOIs
Publication statusAccepted/In press - 2019 Jan 1

Keywords

  • fiberphotometry
  • goal-directed behavior
  • motivation
  • operant conditioning
  • optogenetics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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