Translocation (8; 22) (q24; q11) and Epstein-Barr viral genome in a case of Burkitt's type of acute lymphoblastic leukemia (L3)

T. Watanabe, Shinichiro Okamoto, H. Nakamura, N. Sadamori, K. Kinoshita, M. Ichimaru

Research output: Contribution to journalArticle

Abstract

A case of Burkitt's type of acute lymphoblastic leukemia (FAB L3) in an 80-year-old male patient is reported. At the time of diagnosis, 74% of the bone marrow cells were lymphoblastoid cells, which were large and homogeneous in size, and whose cytoplasm was abundant and intensely basophilic containing many vacuoles. Lambda-light chains were detected as surface immunoglobulin (Ig), but not heavy chains or kappa-light chains. Epstein-Barr (EB) viral genome was detected in the cultured bone marrow cells by spot hybridization method. Chromosomal banding studies of bone marrow cells revealed t(8; 22) (q24; q11) in all the 18 metaphases examined. This translocation brings the Ig lambda-light chain gene on chromosome 22q11 to chromosome 8q24 where the c-myc proto-oncogene is localized, which is thought to be closely associated with the leukemogenesis of this disorder, whereas EB viral genome is observed in African Burkitt's lymphoma. To our best knowledge, however, there have been no reported Japanese patients with L3 ALL in whom t(8; 22) or EB viral genome was observed.

Original languageEnglish
Pages (from-to)211-215
Number of pages5
Journal[Rinsho ketsueki] The Japanese journal of clinical hematology
Volume30
Issue number2
Publication statusPublished - 1989 Feb
Externally publishedYes

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Viral Genome
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Bone Marrow Cells
Burkitt Lymphoma
Immunoglobulin Light Chain Genes
Chromosomes
Light
Immunoglobulin Heavy Chains
B-Cell Antigen Receptors
myc Genes
Metaphase
Vacuoles
Cultured Cells
Cytoplasm

ASJC Scopus subject areas

  • Medicine(all)

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Translocation (8; 22) (q24; q11) and Epstein-Barr viral genome in a case of Burkitt's type of acute lymphoblastic leukemia (L3). / Watanabe, T.; Okamoto, Shinichiro; Nakamura, H.; Sadamori, N.; Kinoshita, K.; Ichimaru, M.

In: [Rinsho ketsueki] The Japanese journal of clinical hematology, Vol. 30, No. 2, 02.1989, p. 211-215.

Research output: Contribution to journalArticle

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