Transmission of chromosomally integrated human herpesvirsus 6 (HHV-6) variant A from a parent to children leading to misdiagnosis of active HHV-6 infection

Takehiko Mori, K. Tanaka-Taya, H. Satoh, Y. Aisa, Rie Yamazaki, Jun Kato, Y. Ikeda, Shinichiro Okamoto

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25 Citations (Scopus)

Abstract

Only a handful of cases of chromosomally integrated human herpesvirus 6 (CI-HHV-6) have been reported, suggesting that this phenomenon is rare. We here present a familial case of HHV-6 variant A (HHV-6A) transmission through a generation, which was identified in the setting of allogeneic hematopoietic stem cell transplantation (HSCT). A 31-year-old man with myelodysplastic syndrome underwent allogeneic HSCT from a human leukocyte antigen-identical sibling, and was found to be continuously yielding high copy numbers of HHV-6A DNA in plasma evaluated by real-time polymerase chain reaction (PCR). Antiviral therapy with ganciclovir or foscarnet failed to decrease the copy numbers. HHV-6A DNA was detected in the patient's buccal mucosa and hair follicles, and was also detected in the plasma, whole blood, and buccal mucosa of the patient's father and 2 siblings, but not in his mother. The sequences of HHV-6A DNA isolated from all family members were identical. Since monitoring of HHV-6 by PCR has been widely introduced to the field of HSCT, transplant physicians should be aware of such an alternative form of HHV-6 transmission, particularly when HHV-6A is detected.

Original languageEnglish
Pages (from-to)503-506
Number of pages4
JournalTransplant Infectious Disease
Volume11
Issue number6
DOIs
Publication statusPublished - 2009 Dec

Fingerprint

Human Herpesvirus 6
Diagnostic Errors
Hematopoietic Stem Cell Transplantation
Infection
Mouth Mucosa
Siblings
DNA
Foscarnet
Ganciclovir
Hair Follicle
Myelodysplastic Syndromes
HLA Antigens
Fathers
Antiviral Agents
Real-Time Polymerase Chain Reaction
Mothers
Physicians
Transplants
Polymerase Chain Reaction

Keywords

  • Chromosomally integrated HHV-6
  • Hematopoietic stem cell transplantation
  • HHV-6 variant A
  • Human herpesvirus 6 (HHV-6)
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Cite this

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title = "Transmission of chromosomally integrated human herpesvirsus 6 (HHV-6) variant A from a parent to children leading to misdiagnosis of active HHV-6 infection",
abstract = "Only a handful of cases of chromosomally integrated human herpesvirus 6 (CI-HHV-6) have been reported, suggesting that this phenomenon is rare. We here present a familial case of HHV-6 variant A (HHV-6A) transmission through a generation, which was identified in the setting of allogeneic hematopoietic stem cell transplantation (HSCT). A 31-year-old man with myelodysplastic syndrome underwent allogeneic HSCT from a human leukocyte antigen-identical sibling, and was found to be continuously yielding high copy numbers of HHV-6A DNA in plasma evaluated by real-time polymerase chain reaction (PCR). Antiviral therapy with ganciclovir or foscarnet failed to decrease the copy numbers. HHV-6A DNA was detected in the patient's buccal mucosa and hair follicles, and was also detected in the plasma, whole blood, and buccal mucosa of the patient's father and 2 siblings, but not in his mother. The sequences of HHV-6A DNA isolated from all family members were identical. Since monitoring of HHV-6 by PCR has been widely introduced to the field of HSCT, transplant physicians should be aware of such an alternative form of HHV-6 transmission, particularly when HHV-6A is detected.",
keywords = "Chromosomally integrated HHV-6, Hematopoietic stem cell transplantation, HHV-6 variant A, Human herpesvirus 6 (HHV-6), Polymerase chain reaction",
author = "Takehiko Mori and K. Tanaka-Taya and H. Satoh and Y. Aisa and Rie Yamazaki and Jun Kato and Y. Ikeda and Shinichiro Okamoto",
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T1 - Transmission of chromosomally integrated human herpesvirsus 6 (HHV-6) variant A from a parent to children leading to misdiagnosis of active HHV-6 infection

AU - Mori, Takehiko

AU - Tanaka-Taya, K.

AU - Satoh, H.

AU - Aisa, Y.

AU - Yamazaki, Rie

AU - Kato, Jun

AU - Ikeda, Y.

AU - Okamoto, Shinichiro

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AB - Only a handful of cases of chromosomally integrated human herpesvirus 6 (CI-HHV-6) have been reported, suggesting that this phenomenon is rare. We here present a familial case of HHV-6 variant A (HHV-6A) transmission through a generation, which was identified in the setting of allogeneic hematopoietic stem cell transplantation (HSCT). A 31-year-old man with myelodysplastic syndrome underwent allogeneic HSCT from a human leukocyte antigen-identical sibling, and was found to be continuously yielding high copy numbers of HHV-6A DNA in plasma evaluated by real-time polymerase chain reaction (PCR). Antiviral therapy with ganciclovir or foscarnet failed to decrease the copy numbers. HHV-6A DNA was detected in the patient's buccal mucosa and hair follicles, and was also detected in the plasma, whole blood, and buccal mucosa of the patient's father and 2 siblings, but not in his mother. The sequences of HHV-6A DNA isolated from all family members were identical. Since monitoring of HHV-6 by PCR has been widely introduced to the field of HSCT, transplant physicians should be aware of such an alternative form of HHV-6 transmission, particularly when HHV-6A is detected.

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KW - Polymerase chain reaction

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