TY - JOUR
T1 - Transmission of hepatitis B virus (HBV) genotypes among Japanese immigrants and natives in Bolivia
AU - Khan, Anis
AU - Tanaka, Yasuhito
AU - Saito, Hidetsugu
AU - Ebinuma, Hirotoshi
AU - Sekiguchi, Hitoshi
AU - Iwama, Hideaki
AU - Wakabayashi, Go
AU - Kamiya, Toshio
AU - Kurbanov, Fuat
AU - Elkady, Abeer
AU - Mizokami, Masashi
N1 - Funding Information:
This study was supported in part by Ministry of Health, Labor and Welfare of Japan. A.K. was supported by the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.
PY - 2008/3
Y1 - 2008/3
N2 - Hepatitis B virus genotypes are associated with transmission pattern, virological and clinical features and outcome of the chronic infection course. HBV genotypes other than Genotype F (HBV/F) are considered a reflection of human migration into South America. A total of 487 individuals in Bolivia, including Japanese immigrants (n = 287) and natives (n = 200), were screened for HBV serological markers. Overall 22/487 (4.5%) of the subjects were positive for HBsAg, 217/487 (44.5%) for anti-HBc and 162/487 (33.3%) for anti-HBs. Genotypes were determinable in 22 cases by EIA, followed by sequencing and phylogenetic analysis in 17 cases. HBV genotype distribution in Japanese and Bolivians was HBV/F (4 and 8); HBV/C (5 and 3); and HBV/B (1 and 1), respectively. Phylogenetic analyses of nine complete and eight partial (HBsAg/pre-core/core region) genomes, revealed that HBV/F strains cluster with previously reported regional strains, whereas HBV/B and HBV/C strains belonged to Asian subgenotype B2 (Ba) and C2 (Ce), respectively. Japanese immigrants might have introduced HBV/B and HBV/C to natives in Bolivia, conversely, exposed to the indigenous HBV/F. This report provides evidence of an inter-communities transmission of HBV revealed by its genotypes. Further study is required to investigate peculiarities of the genotypes in different ethnic groups in Bolivia.
AB - Hepatitis B virus genotypes are associated with transmission pattern, virological and clinical features and outcome of the chronic infection course. HBV genotypes other than Genotype F (HBV/F) are considered a reflection of human migration into South America. A total of 487 individuals in Bolivia, including Japanese immigrants (n = 287) and natives (n = 200), were screened for HBV serological markers. Overall 22/487 (4.5%) of the subjects were positive for HBsAg, 217/487 (44.5%) for anti-HBc and 162/487 (33.3%) for anti-HBs. Genotypes were determinable in 22 cases by EIA, followed by sequencing and phylogenetic analysis in 17 cases. HBV genotype distribution in Japanese and Bolivians was HBV/F (4 and 8); HBV/C (5 and 3); and HBV/B (1 and 1), respectively. Phylogenetic analyses of nine complete and eight partial (HBsAg/pre-core/core region) genomes, revealed that HBV/F strains cluster with previously reported regional strains, whereas HBV/B and HBV/C strains belonged to Asian subgenotype B2 (Ba) and C2 (Ce), respectively. Japanese immigrants might have introduced HBV/B and HBV/C to natives in Bolivia, conversely, exposed to the indigenous HBV/F. This report provides evidence of an inter-communities transmission of HBV revealed by its genotypes. Further study is required to investigate peculiarities of the genotypes in different ethnic groups in Bolivia.
KW - Bolivians
KW - Genotypes
KW - HBV
KW - Japanese immigrants
KW - Transmission
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U2 - 10.1016/j.virusres.2007.12.005
DO - 10.1016/j.virusres.2007.12.005
M3 - Article
C2 - 18207274
AN - SCOPUS:39149136850
SN - 0168-1702
VL - 132
SP - 174
EP - 180
JO - Virus Research
JF - Virus Research
IS - 1-2
ER -
