Transplantability and Sensitivity to Natural Killer Cells of Aclarubicin-resistant Murine Lymphoma

Yoshikazu Sugimoto, Yoko Hirakawa, Nobuyuki Tanaka, Makoto Tahara, Isao Sato, Toshio Nishimura, Hideo Suzuki, Nobuo Tanaka

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

DBA/2 mice implanted i.p. with an aclarubicin (ACR)–resistant subline of L5178Y cells survived 4- to 5-fold longer than those with the parental cells; and animals with the Adriamycin- or bleomycin–resistant subline displayed an intermediate survival period. The i.p. treatment of mice with cyclophosphamide markedly enhanced i.p. growth of the ACR–resistant cells, suggesting that A certain host defense mechanism participates in the lower transplantability. In vitro, the ACR–resistant subline showed much higher sensitivity to natural killer cells. The i.p. pretreatment with anti-asialo-GM1 antibody markedly reduced the mean survival period of mice implanted i.p. with the ACR–resistant cells, suggesting that natural killer cells play an important role in the defense against transplantation of the ACR–resistant cells. copyright.

Original languageEnglish
Pages (from-to)5646-5648
Number of pages3
JournalCancer Research
Volume46
Issue number11
Publication statusPublished - 1986 Nov 1
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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