Transplantation of neural stem cells into spinal cord after injury

Masaya Nakamura, Yoshiaki Toyama

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Recovery from central nervous system damage in adult mammals is hindered by their limited ability to replace lost cells and damaged myelin, and reestablish functional neural connections. However, recent progresses in stem cell biology are making it feasible to induce the regeneration of injured axons after spinal cord injury. Transplantation of in vitro expanded neural stem cells into rat spinal cord 9 days after contusion injury induced their differentiation into neurons and oligodendrocytes, and the functional recovery of skilled forelimb movement. It was partly because the microenvironment within the injured spinal cord at 9 days after injury was more favorable for grafted neural stem cells in terms of their survival and differentiation.

Original languageEnglish
Pages (from-to)463-468
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Volume61
Issue number3
Publication statusPublished - 2003

Fingerprint

Neural Stem Cells
Spinal Cord Injuries
Spinal Cord
Transplantation
Forelimb
Contusions
Oligodendroglia
Wounds and Injuries
Myelin Sheath
Axons
Cell Biology
Regeneration
Mammals
Stem Cells
Central Nervous System
Neurons
In Vitro Techniques

Cite this

Transplantation of neural stem cells into spinal cord after injury. / Nakamura, Masaya; Toyama, Yoshiaki.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 61, No. 3, 2003, p. 463-468.

Research output: Contribution to journalArticle

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