Treatment of rheumatoid arthritis with biological agents-as a typical and common immune-mediated inflammatory disease

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Molecules involved in the disease process facilitated our understanding of pathogenesis of the disease with unknown etiology such as immune-mediated and inflammatory diseases. Moreover, the targeted therapies against the proposed molecular targets by biological agents provide enormous benefits to the patients and societies. Here, I will review recent progress of the biological treatment in the immune-inflammatory diseases by focusing on the rheumatoid arthritis, the disease characterized by persistent polyarthritis leading to joint destruction and disability with autoimmune features, as a role model.

Original languageEnglish
Pages (from-to)600-608
Number of pages9
JournalProceedings of the Japan Academy Series B: Physical and Biological Sciences
Issue number8
Publication statusPublished - 2017



  • Biologics
  • Cytokines
  • Immune-mediated inflammatory diseases
  • Rheumatoid arthritis
  • Therapy

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Physics and Astronomy(all)

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