[Treatment of S-1 plus weekly CDDP for advanced gastric cancer].

Takeshi Kemmochi, Tomohisa Egawa, Yasunori Mihara, Tomoyuki Irino, Yasuhiro Ito, Atsushi Nagashima, Hiroyuki Makino, Wataru Yamamuro

Research output: Contribution to journalArticle

Abstract

We analyzed the clinical efficacy and safety of chemotherapy using S-1 plus weekly CDDP( w-CS therapy) for unresectable gastric cancer. Twenty one patients were treated with this treatment. S-1 80 mg/m2/day was administered for 2 weeks followed by a 1-week rest. CDDP 20 mg/m2 was injected intravenously on day 1 and 8. The overall response rate was 52. 3%. The disease control rate was 85.7%. Grade 3 or 4 major toxicity comprised neutropenia (14.2%), thrombocytopenia (4.7%) and plasma creatinine elevation (4.7%). w-CS therapy is satisfied resulting with efficacy and safety. Thus, future clinical trials and accumulation of futher cases are warranted.

Original languageEnglish
Pages (from-to)2351-2353
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume38
Issue number12
Publication statusPublished - 2011 Jan 1
Externally publishedYes

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Stomach Neoplasms
Safety
Neutropenia
Thrombocytopenia
Creatinine
Therapeutics
Clinical Trials
Drug Therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Kemmochi, T., Egawa, T., Mihara, Y., Irino, T., Ito, Y., Nagashima, A., ... Yamamuro, W. (2011). [Treatment of S-1 plus weekly CDDP for advanced gastric cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 38(12), 2351-2353.

[Treatment of S-1 plus weekly CDDP for advanced gastric cancer]. / Kemmochi, Takeshi; Egawa, Tomohisa; Mihara, Yasunori; Irino, Tomoyuki; Ito, Yasuhiro; Nagashima, Atsushi; Makino, Hiroyuki; Yamamuro, Wataru.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 38, No. 12, 01.01.2011, p. 2351-2353.

Research output: Contribution to journalArticle

Kemmochi, T, Egawa, T, Mihara, Y, Irino, T, Ito, Y, Nagashima, A, Makino, H & Yamamuro, W 2011, '[Treatment of S-1 plus weekly CDDP for advanced gastric cancer].', Gan to kagaku ryoho. Cancer & chemotherapy, vol. 38, no. 12, pp. 2351-2353.
Kemmochi T, Egawa T, Mihara Y, Irino T, Ito Y, Nagashima A et al. [Treatment of S-1 plus weekly CDDP for advanced gastric cancer]. Gan to kagaku ryoho. Cancer & chemotherapy. 2011 Jan 1;38(12):2351-2353.
Kemmochi, Takeshi ; Egawa, Tomohisa ; Mihara, Yasunori ; Irino, Tomoyuki ; Ito, Yasuhiro ; Nagashima, Atsushi ; Makino, Hiroyuki ; Yamamuro, Wataru. / [Treatment of S-1 plus weekly CDDP for advanced gastric cancer]. In: Gan to kagaku ryoho. Cancer & chemotherapy. 2011 ; Vol. 38, No. 12. pp. 2351-2353.
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