[Treatment of S-1 plus weekly CDDP for advanced gastric cancer].

Takeshi Kemmochi; Tomohisa Egawa; Yasunori Mihara; Tomoyuki Irino; Yasuhiro Ito; Atsushi Nagashima; Hiroyuki Makino; Wataru Yamamuro

[Treatment of S-1 plus weekly CDDP for advanced gastric cancer].

Takeshi Kemmochi, Tomohisa Egawa, Yasunori Mihara, Tomoyuki Irino, Yasuhiro Ito, Atsushi Nagashima, Hiroyuki Makino, Wataru Yamamuro

Research output: Contribution to journal › Article

Abstract

We analyzed the clinical efficacy and safety of chemotherapy using S-1 plus weekly CDDP( w-CS therapy) for unresectable gastric cancer. Twenty one patients were treated with this treatment. S-1 80 mg/m²/day was administered for 2 weeks followed by a 1-week rest. CDDP 20 mg/m² was injected intravenously on day 1 and 8. The overall response rate was 52. 3%. The disease control rate was 85.7%. Grade 3 or 4 major toxicity comprised neutropenia (14.2%), thrombocytopenia (4.7%) and plasma creatinine elevation (4.7%). w-CS therapy is satisfied resulting with efficacy and safety. Thus, future clinical trials and accumulation of futher cases are warranted.

Original language	English
Pages (from-to)	2351-2353
Number of pages	3
Journal	Gan to kagaku ryoho. Cancer & chemotherapy
Volume	38
Issue number	12
Publication status	Published - 2011 Nov
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "[Treatment of S-1 plus weekly CDDP for advanced gastric cancer].",

abstract = "We analyzed the clinical efficacy and safety of chemotherapy using S-1 plus weekly CDDP( w-CS therapy) for unresectable gastric cancer. Twenty one patients were treated with this treatment. S-1 80 mg/m2/day was administered for 2 weeks followed by a 1-week rest. CDDP 20 mg/m2 was injected intravenously on day 1 and 8. The overall response rate was 52. 3%. The disease control rate was 85.7%. Grade 3 or 4 major toxicity comprised neutropenia (14.2%), thrombocytopenia (4.7%) and plasma creatinine elevation (4.7%). w-CS therapy is satisfied resulting with efficacy and safety. Thus, future clinical trials and accumulation of futher cases are warranted.",

author = "Takeshi Kemmochi and Tomohisa Egawa and Yasunori Mihara and Tomoyuki Irino and Yasuhiro Ito and Atsushi Nagashima and Hiroyuki Makino and Wataru Yamamuro",

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AU - Kemmochi, Takeshi

AU - Egawa, Tomohisa

AU - Mihara, Yasunori

AU - Irino, Tomoyuki

AU - Ito, Yasuhiro

AU - Nagashima, Atsushi

AU - Makino, Hiroyuki

AU - Yamamuro, Wataru

PY - 2011/11

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N2 - We analyzed the clinical efficacy and safety of chemotherapy using S-1 plus weekly CDDP( w-CS therapy) for unresectable gastric cancer. Twenty one patients were treated with this treatment. S-1 80 mg/m2/day was administered for 2 weeks followed by a 1-week rest. CDDP 20 mg/m2 was injected intravenously on day 1 and 8. The overall response rate was 52. 3%. The disease control rate was 85.7%. Grade 3 or 4 major toxicity comprised neutropenia (14.2%), thrombocytopenia (4.7%) and plasma creatinine elevation (4.7%). w-CS therapy is satisfied resulting with efficacy and safety. Thus, future clinical trials and accumulation of futher cases are warranted.

AB - We analyzed the clinical efficacy and safety of chemotherapy using S-1 plus weekly CDDP( w-CS therapy) for unresectable gastric cancer. Twenty one patients were treated with this treatment. S-1 80 mg/m2/day was administered for 2 weeks followed by a 1-week rest. CDDP 20 mg/m2 was injected intravenously on day 1 and 8. The overall response rate was 52. 3%. The disease control rate was 85.7%. Grade 3 or 4 major toxicity comprised neutropenia (14.2%), thrombocytopenia (4.7%) and plasma creatinine elevation (4.7%). w-CS therapy is satisfied resulting with efficacy and safety. Thus, future clinical trials and accumulation of futher cases are warranted.

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