Treatment of secondary infection, especially septicemia in hematological patients with KW-1070

Keisuke Toyama, Shinichiro Kamoto, Hiroshi Okada

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Abstract

Nine hematological patients as acute leukemia, aplastic anemia and multiple myeloma were treated with KW-1070, a new aminoglycoside, or in combination with other antibiotics. Maximum blood concentration measured by radioimmunoassay was about 14 µg/ml when 200 mg of KW-1070 was given by one-hour drip intravenous infusion as well as by intramuscular injection. Out of 9 cases consisted of 4 cases with septicemia, 4 possible septicemia and 1 urinary tract infection, 4 cases were cured by treatment with KW-1070. Septicemin caused by Klebsiella pneumoniae in a case with acute leukemia was cured by treatment with KW-1070 and cephalothin, as Klebsiella isolated from the patient was sensitive to KW-1070 while not gentamicin or dibekacin. In none of 9 cases, any side effect snch as hearing disturbance or impaired renal function was observed.

Original languageEnglish
Pages (from-to)270-274
Number of pages5
JournalChemotherapy
Volume29
Issue numberS-2
DOIs
Publication statusPublished - 1981 Jan 1

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ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology
  • Drug Discovery
  • Oncology

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