Treatment results of non-small cell lung cancer in octogenerians

Tadashi Uehara, Tokujiro Yano, Hideki Yokoyama, Yasuro Fukuyama, Hiroshi Asoh, Takanori Kanematsu, Yasuhiro Terazaki, Shinji Kuninaka, Yukito Ichinose

Research output: Contribution to journalArticle

Abstract

Objective: In order to establish the treatment of non-small cell lung cancer in octogenarians we retrospectively reviewed our experiences. Patients: The present study included 109 patients with a mean age of 82 ranging from 80 to 94, who were treated at our institute from 1972 through 1996. There were 74 men and 35 women. Sixty-one patients had adenocarcinoma, 35 had squamous cell carcinoma and 13 had other histological types. Thirty patients had clinical stage I disease, 13 had stage II, 22 had stage IIIA, 12 had stage IIIB and 32 had stage IV. Results: In clinical stage I, 18 patients (58.1%) underwent an operation with a 5 year-survival rate of 48.6%, including two operation-related deaths. On the other hand, no patients survived 5 years after either radiation treatment (6 patients) or other treatment (6 patients). In clinical stage III, only 3 patients underwent surgical resection. Twenty patients received radiotherapy with (2 patients) or without (18 patients) chemotherapy. There were 5 treatment-related deaths (25%). Concerning other patients, 3 received chemotherapy, 2 received pleural drainage, and 6 had no other treatment. There was no significant difference in survival between the radiotherapy group and the other treatment group (MST 8M : 20M, p=0.36). In clinical stage IV, there was no significant difference in survival between the treatment group (systemic chemotherapy, radiotherapy, etc.; n = 19) and the non-treatment group (n=13). Conclusion: In clinical stage I, surgical resection is considered to be the treatment of choice while the best supportive care is so in the advanced stages.

Original languageEnglish
Pages (from-to)215-221
Number of pages7
JournalJapanese Journal of Lung Cancer
Volume38
Issue number3
Publication statusPublished - 1998 Jun
Externally publishedYes

Fingerprint

Non-Small Cell Lung Carcinoma
Therapeutics
Radiotherapy
Drug Therapy
Survival
Drainage
Squamous Cell Carcinoma
Adenocarcinoma
Survival Rate
Radiation

Keywords

  • Best supportive care
  • Non-small cell lung cancer
  • Octogenerians
  • Operation
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Uehara, T., Yano, T., Yokoyama, H., Fukuyama, Y., Asoh, H., Kanematsu, T., ... Ichinose, Y. (1998). Treatment results of non-small cell lung cancer in octogenerians. Japanese Journal of Lung Cancer, 38(3), 215-221.

Treatment results of non-small cell lung cancer in octogenerians. / Uehara, Tadashi; Yano, Tokujiro; Yokoyama, Hideki; Fukuyama, Yasuro; Asoh, Hiroshi; Kanematsu, Takanori; Terazaki, Yasuhiro; Kuninaka, Shinji; Ichinose, Yukito.

In: Japanese Journal of Lung Cancer, Vol. 38, No. 3, 06.1998, p. 215-221.

Research output: Contribution to journalArticle

Uehara, T, Yano, T, Yokoyama, H, Fukuyama, Y, Asoh, H, Kanematsu, T, Terazaki, Y, Kuninaka, S & Ichinose, Y 1998, 'Treatment results of non-small cell lung cancer in octogenerians', Japanese Journal of Lung Cancer, vol. 38, no. 3, pp. 215-221.
Uehara T, Yano T, Yokoyama H, Fukuyama Y, Asoh H, Kanematsu T et al. Treatment results of non-small cell lung cancer in octogenerians. Japanese Journal of Lung Cancer. 1998 Jun;38(3):215-221.
Uehara, Tadashi ; Yano, Tokujiro ; Yokoyama, Hideki ; Fukuyama, Yasuro ; Asoh, Hiroshi ; Kanematsu, Takanori ; Terazaki, Yasuhiro ; Kuninaka, Shinji ; Ichinose, Yukito. / Treatment results of non-small cell lung cancer in octogenerians. In: Japanese Journal of Lung Cancer. 1998 ; Vol. 38, No. 3. pp. 215-221.
@article{bb79b07204834dfbb916775897e407ed,
title = "Treatment results of non-small cell lung cancer in octogenerians",
abstract = "Objective: In order to establish the treatment of non-small cell lung cancer in octogenarians we retrospectively reviewed our experiences. Patients: The present study included 109 patients with a mean age of 82 ranging from 80 to 94, who were treated at our institute from 1972 through 1996. There were 74 men and 35 women. Sixty-one patients had adenocarcinoma, 35 had squamous cell carcinoma and 13 had other histological types. Thirty patients had clinical stage I disease, 13 had stage II, 22 had stage IIIA, 12 had stage IIIB and 32 had stage IV. Results: In clinical stage I, 18 patients (58.1{\%}) underwent an operation with a 5 year-survival rate of 48.6{\%}, including two operation-related deaths. On the other hand, no patients survived 5 years after either radiation treatment (6 patients) or other treatment (6 patients). In clinical stage III, only 3 patients underwent surgical resection. Twenty patients received radiotherapy with (2 patients) or without (18 patients) chemotherapy. There were 5 treatment-related deaths (25{\%}). Concerning other patients, 3 received chemotherapy, 2 received pleural drainage, and 6 had no other treatment. There was no significant difference in survival between the radiotherapy group and the other treatment group (MST 8M : 20M, p=0.36). In clinical stage IV, there was no significant difference in survival between the treatment group (systemic chemotherapy, radiotherapy, etc.; n = 19) and the non-treatment group (n=13). Conclusion: In clinical stage I, surgical resection is considered to be the treatment of choice while the best supportive care is so in the advanced stages.",
keywords = "Best supportive care, Non-small cell lung cancer, Octogenerians, Operation, Radiotherapy",
author = "Tadashi Uehara and Tokujiro Yano and Hideki Yokoyama and Yasuro Fukuyama and Hiroshi Asoh and Takanori Kanematsu and Yasuhiro Terazaki and Shinji Kuninaka and Yukito Ichinose",
year = "1998",
month = "6",
language = "English",
volume = "38",
pages = "215--221",
journal = "Japanese Journal of Lung Cancer",
issn = "0386-9628",
publisher = "Japan Lung Cancer Society",
number = "3",

}

TY - JOUR

T1 - Treatment results of non-small cell lung cancer in octogenerians

AU - Uehara, Tadashi

AU - Yano, Tokujiro

AU - Yokoyama, Hideki

AU - Fukuyama, Yasuro

AU - Asoh, Hiroshi

AU - Kanematsu, Takanori

AU - Terazaki, Yasuhiro

AU - Kuninaka, Shinji

AU - Ichinose, Yukito

PY - 1998/6

Y1 - 1998/6

N2 - Objective: In order to establish the treatment of non-small cell lung cancer in octogenarians we retrospectively reviewed our experiences. Patients: The present study included 109 patients with a mean age of 82 ranging from 80 to 94, who were treated at our institute from 1972 through 1996. There were 74 men and 35 women. Sixty-one patients had adenocarcinoma, 35 had squamous cell carcinoma and 13 had other histological types. Thirty patients had clinical stage I disease, 13 had stage II, 22 had stage IIIA, 12 had stage IIIB and 32 had stage IV. Results: In clinical stage I, 18 patients (58.1%) underwent an operation with a 5 year-survival rate of 48.6%, including two operation-related deaths. On the other hand, no patients survived 5 years after either radiation treatment (6 patients) or other treatment (6 patients). In clinical stage III, only 3 patients underwent surgical resection. Twenty patients received radiotherapy with (2 patients) or without (18 patients) chemotherapy. There were 5 treatment-related deaths (25%). Concerning other patients, 3 received chemotherapy, 2 received pleural drainage, and 6 had no other treatment. There was no significant difference in survival between the radiotherapy group and the other treatment group (MST 8M : 20M, p=0.36). In clinical stage IV, there was no significant difference in survival between the treatment group (systemic chemotherapy, radiotherapy, etc.; n = 19) and the non-treatment group (n=13). Conclusion: In clinical stage I, surgical resection is considered to be the treatment of choice while the best supportive care is so in the advanced stages.

AB - Objective: In order to establish the treatment of non-small cell lung cancer in octogenarians we retrospectively reviewed our experiences. Patients: The present study included 109 patients with a mean age of 82 ranging from 80 to 94, who were treated at our institute from 1972 through 1996. There were 74 men and 35 women. Sixty-one patients had adenocarcinoma, 35 had squamous cell carcinoma and 13 had other histological types. Thirty patients had clinical stage I disease, 13 had stage II, 22 had stage IIIA, 12 had stage IIIB and 32 had stage IV. Results: In clinical stage I, 18 patients (58.1%) underwent an operation with a 5 year-survival rate of 48.6%, including two operation-related deaths. On the other hand, no patients survived 5 years after either radiation treatment (6 patients) or other treatment (6 patients). In clinical stage III, only 3 patients underwent surgical resection. Twenty patients received radiotherapy with (2 patients) or without (18 patients) chemotherapy. There were 5 treatment-related deaths (25%). Concerning other patients, 3 received chemotherapy, 2 received pleural drainage, and 6 had no other treatment. There was no significant difference in survival between the radiotherapy group and the other treatment group (MST 8M : 20M, p=0.36). In clinical stage IV, there was no significant difference in survival between the treatment group (systemic chemotherapy, radiotherapy, etc.; n = 19) and the non-treatment group (n=13). Conclusion: In clinical stage I, surgical resection is considered to be the treatment of choice while the best supportive care is so in the advanced stages.

KW - Best supportive care

KW - Non-small cell lung cancer

KW - Octogenerians

KW - Operation

KW - Radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=0031845021&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031845021&partnerID=8YFLogxK

M3 - Article

VL - 38

SP - 215

EP - 221

JO - Japanese Journal of Lung Cancer

JF - Japanese Journal of Lung Cancer

SN - 0386-9628

IS - 3

ER -