Treatment with a Gamma-Secretase Inhibitor Promotes Functional Recovery in Human iPSC- Derived Transplants for Chronic Spinal Cord Injury

Toshiki Okubo, Narihito Nagoshi, Jun Kohyama, Osahiko Tsuji, Munehisa Shinozaki, Shinsuke Shibata, Yoshitaka Kase, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In this article, Okano and colleagues show that the GSI-treated hiPSC-NS/PCs caused significantly enhanced axonal regrowth, remyelination, inhibitory synapse formation with the host neural circuitry, and reticulo spinal tract fiber formation. These favorable outcomes contributed to motor function improvement. Therefore, treating cells with GSI provides a beneficial effect after transplantation, even in the chronic phase following SCI.

Original languageEnglish
Pages (from-to)1416-1432
Number of pages17
JournalStem cell reports
Volume11
Issue number6
DOIs
Publication statusPublished - 2018 Dec 11

Keywords

  • Notch signaling
  • axonal regrowth
  • chronic spinal cord injury
  • gamma-secretase inhibitor
  • iPS cell
  • motor function
  • p38 MAPK
  • regenerative medicine
  • transplantation

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

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