Treatment with a Gamma-Secretase Inhibitor Promotes Functional Recovery in Human iPSC- Derived Transplants for Chronic Spinal Cord Injury

Toshiki Okubo, Narihito Nagoshi, Jun Kohyama, Osahiko Tsuji, Munehisa Shinozaki, Shinsuke Shibata, Yoshitaka Kase, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In this article, Okano and colleagues show that the GSI-treated hiPSC-NS/PCs caused significantly enhanced axonal regrowth, remyelination, inhibitory synapse formation with the host neural circuitry, and reticulo spinal tract fiber formation. These favorable outcomes contributed to motor function improvement. Therefore, treating cells with GSI provides a beneficial effect after transplantation, even in the chronic phase following SCI.

Original languageEnglish
Pages (from-to)1416-1432
Number of pages17
JournalStem Cell Reports
Volume11
Issue number6
DOIs
Publication statusPublished - 2018 Dec 11

Fingerprint

Induced Pluripotent Stem Cells
Amyloid Precursor Protein Secretases
Transplants
Spinal Cord Injuries
Synapses
Transplantation
Recovery
Fibers

Keywords

  • axonal regrowth
  • chronic spinal cord injury
  • gamma-secretase inhibitor
  • iPS cell
  • motor function
  • Notch signaling
  • p38 MAPK
  • regenerative medicine
  • transplantation

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

Cite this

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abstract = "In this article, Okano and colleagues show that the GSI-treated hiPSC-NS/PCs caused significantly enhanced axonal regrowth, remyelination, inhibitory synapse formation with the host neural circuitry, and reticulo spinal tract fiber formation. These favorable outcomes contributed to motor function improvement. Therefore, treating cells with GSI provides a beneficial effect after transplantation, even in the chronic phase following SCI.",
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AU - Okubo, Toshiki

AU - Nagoshi, Narihito

AU - Kohyama, Jun

AU - Tsuji, Osahiko

AU - Shinozaki, Munehisa

AU - Shibata, Shinsuke

AU - Kase, Yoshitaka

AU - Matsumoto, Morio

AU - Nakamura, Masaya

AU - Okano, Hideyuki

PY - 2018/12/11

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AB - In this article, Okano and colleagues show that the GSI-treated hiPSC-NS/PCs caused significantly enhanced axonal regrowth, remyelination, inhibitory synapse formation with the host neural circuitry, and reticulo spinal tract fiber formation. These favorable outcomes contributed to motor function improvement. Therefore, treating cells with GSI provides a beneficial effect after transplantation, even in the chronic phase following SCI.

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KW - chronic spinal cord injury

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KW - motor function

KW - Notch signaling

KW - p38 MAPK

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