Trends and characteristics of epithelial ovarian cancer in Japan between 2002 and 2015: A JSGO–JSOG joint study

Hiroko Machida, Koji Matsuo, Wataru Yamagami, Yasuhiko Ebina, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kanauchi, Satoru Nagase, Takayuki Enomoto, Mikio Mikami

Research output: Contribution to journalArticle

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Abstract

Objective: To examine the trends of epithelial ovarian cancer histologic subtypes in Japan. Methods: A nationwide retrospective registry study was performed between 2002 and 2015 (Japan cohort, n = 48,640). Trends were also examined in The Surveillance, Epidemiology, and End Results Program (US cohort, n = 49,936). Time-specific proportional changes of four major histological subtypes (serous, clear cell, endometrioid, and mucinous) were examined. Results: The Japan cohort had more stage I disease (44.1% versus 24.9%) and less stage IV disease (10.0% versus 23.1%) than the US cohort (P < 0.001). The Japan cohort had more non-serous histology, particularly clear cell carcinoma (26.9% versus 8.4%), than the US cohort (P < 0.001). In the Japan cohort, proportion of clear cell carcinoma increased significantly from 23.4% to 29.1% between 2002 and 2010 (P < 0.001). Among stage I disease, clear cell carcinoma increased significantly in the Japan cohort from 32.9% to 40.3% between 2002 and 2015 (P < 0.001), whereas mucinous carcinoma increased significantly in the US cohort from 15.0% to 24.8% (P = 0.01). In 2015, clear cell carcinoma was most common among women aged <50 years from the Japan cohort (30.2%) versus serous carcinoma in the US cohort (50.8%). In the Japan cohort, the peak age was 75 years for serous, 57 for clear cell, and 45 for endometrioid carcinoma (P < 0.001). Mucinous carcinoma decreased until 43 years and increased again after age 73 years (P < 0.001). Conclusion: Characteristics of epithelial ovarian cancer in Japan are largely different compared to the US. In Japan, clear cell carcinoma has increased significantly in recent years to account for nearly 30% of epithelial ovarian cancer.

Original languageEnglish
JournalGynecologic Oncology
DOIs
Publication statusPublished - 2019 Jan 1

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Japan
Carcinoma
Mucinous Adenocarcinoma
Ovarian epithelial cancer
SEER Program
Endometrioid Carcinoma
Registries
Histology
Retrospective Studies

Keywords

  • Clear cell
  • Histology
  • Ovarian cancer
  • Stage
  • Survival
  • Trends

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Trends and characteristics of epithelial ovarian cancer in Japan between 2002 and 2015 : A JSGO–JSOG joint study. / Machida, Hiroko; Matsuo, Koji; Yamagami, Wataru; Ebina, Yasuhiko; Kobayashi, Yoichi; Tabata, Tsutomu; Kanauchi, Masanori; Nagase, Satoru; Enomoto, Takayuki; Mikami, Mikio.

In: Gynecologic Oncology, 01.01.2019.

Research output: Contribution to journalArticle

Machida, Hiroko ; Matsuo, Koji ; Yamagami, Wataru ; Ebina, Yasuhiko ; Kobayashi, Yoichi ; Tabata, Tsutomu ; Kanauchi, Masanori ; Nagase, Satoru ; Enomoto, Takayuki ; Mikami, Mikio. / Trends and characteristics of epithelial ovarian cancer in Japan between 2002 and 2015 : A JSGO–JSOG joint study. In: Gynecologic Oncology. 2019.
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abstract = "Objective: To examine the trends of epithelial ovarian cancer histologic subtypes in Japan. Methods: A nationwide retrospective registry study was performed between 2002 and 2015 (Japan cohort, n = 48,640). Trends were also examined in The Surveillance, Epidemiology, and End Results Program (US cohort, n = 49,936). Time-specific proportional changes of four major histological subtypes (serous, clear cell, endometrioid, and mucinous) were examined. Results: The Japan cohort had more stage I disease (44.1{\%} versus 24.9{\%}) and less stage IV disease (10.0{\%} versus 23.1{\%}) than the US cohort (P < 0.001). The Japan cohort had more non-serous histology, particularly clear cell carcinoma (26.9{\%} versus 8.4{\%}), than the US cohort (P < 0.001). In the Japan cohort, proportion of clear cell carcinoma increased significantly from 23.4{\%} to 29.1{\%} between 2002 and 2010 (P < 0.001). Among stage I disease, clear cell carcinoma increased significantly in the Japan cohort from 32.9{\%} to 40.3{\%} between 2002 and 2015 (P < 0.001), whereas mucinous carcinoma increased significantly in the US cohort from 15.0{\%} to 24.8{\%} (P = 0.01). In 2015, clear cell carcinoma was most common among women aged <50 years from the Japan cohort (30.2{\%}) versus serous carcinoma in the US cohort (50.8{\%}). In the Japan cohort, the peak age was 75 years for serous, 57 for clear cell, and 45 for endometrioid carcinoma (P < 0.001). Mucinous carcinoma decreased until 43 years and increased again after age 73 years (P < 0.001). Conclusion: Characteristics of epithelial ovarian cancer in Japan are largely different compared to the US. In Japan, clear cell carcinoma has increased significantly in recent years to account for nearly 30{\%} of epithelial ovarian cancer.",
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author = "Hiroko Machida and Koji Matsuo and Wataru Yamagami and Yasuhiko Ebina and Yoichi Kobayashi and Tsutomu Tabata and Masanori Kanauchi and Satoru Nagase and Takayuki Enomoto and Mikio Mikami",
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T1 - Trends and characteristics of epithelial ovarian cancer in Japan between 2002 and 2015

T2 - A JSGO–JSOG joint study

AU - Machida, Hiroko

AU - Matsuo, Koji

AU - Yamagami, Wataru

AU - Ebina, Yasuhiko

AU - Kobayashi, Yoichi

AU - Tabata, Tsutomu

AU - Kanauchi, Masanori

AU - Nagase, Satoru

AU - Enomoto, Takayuki

AU - Mikami, Mikio

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective: To examine the trends of epithelial ovarian cancer histologic subtypes in Japan. Methods: A nationwide retrospective registry study was performed between 2002 and 2015 (Japan cohort, n = 48,640). Trends were also examined in The Surveillance, Epidemiology, and End Results Program (US cohort, n = 49,936). Time-specific proportional changes of four major histological subtypes (serous, clear cell, endometrioid, and mucinous) were examined. Results: The Japan cohort had more stage I disease (44.1% versus 24.9%) and less stage IV disease (10.0% versus 23.1%) than the US cohort (P < 0.001). The Japan cohort had more non-serous histology, particularly clear cell carcinoma (26.9% versus 8.4%), than the US cohort (P < 0.001). In the Japan cohort, proportion of clear cell carcinoma increased significantly from 23.4% to 29.1% between 2002 and 2010 (P < 0.001). Among stage I disease, clear cell carcinoma increased significantly in the Japan cohort from 32.9% to 40.3% between 2002 and 2015 (P < 0.001), whereas mucinous carcinoma increased significantly in the US cohort from 15.0% to 24.8% (P = 0.01). In 2015, clear cell carcinoma was most common among women aged <50 years from the Japan cohort (30.2%) versus serous carcinoma in the US cohort (50.8%). In the Japan cohort, the peak age was 75 years for serous, 57 for clear cell, and 45 for endometrioid carcinoma (P < 0.001). Mucinous carcinoma decreased until 43 years and increased again after age 73 years (P < 0.001). Conclusion: Characteristics of epithelial ovarian cancer in Japan are largely different compared to the US. In Japan, clear cell carcinoma has increased significantly in recent years to account for nearly 30% of epithelial ovarian cancer.

AB - Objective: To examine the trends of epithelial ovarian cancer histologic subtypes in Japan. Methods: A nationwide retrospective registry study was performed between 2002 and 2015 (Japan cohort, n = 48,640). Trends were also examined in The Surveillance, Epidemiology, and End Results Program (US cohort, n = 49,936). Time-specific proportional changes of four major histological subtypes (serous, clear cell, endometrioid, and mucinous) were examined. Results: The Japan cohort had more stage I disease (44.1% versus 24.9%) and less stage IV disease (10.0% versus 23.1%) than the US cohort (P < 0.001). The Japan cohort had more non-serous histology, particularly clear cell carcinoma (26.9% versus 8.4%), than the US cohort (P < 0.001). In the Japan cohort, proportion of clear cell carcinoma increased significantly from 23.4% to 29.1% between 2002 and 2010 (P < 0.001). Among stage I disease, clear cell carcinoma increased significantly in the Japan cohort from 32.9% to 40.3% between 2002 and 2015 (P < 0.001), whereas mucinous carcinoma increased significantly in the US cohort from 15.0% to 24.8% (P = 0.01). In 2015, clear cell carcinoma was most common among women aged <50 years from the Japan cohort (30.2%) versus serous carcinoma in the US cohort (50.8%). In the Japan cohort, the peak age was 75 years for serous, 57 for clear cell, and 45 for endometrioid carcinoma (P < 0.001). Mucinous carcinoma decreased until 43 years and increased again after age 73 years (P < 0.001). Conclusion: Characteristics of epithelial ovarian cancer in Japan are largely different compared to the US. In Japan, clear cell carcinoma has increased significantly in recent years to account for nearly 30% of epithelial ovarian cancer.

KW - Clear cell

KW - Histology

KW - Ovarian cancer

KW - Stage

KW - Survival

KW - Trends

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