Trends in pediatric bacterial meningitis in Japan (2003-2004)

Keisuke Sunakawa, Masato Nonoyama, Tomohiro Ooishi, Satoshi Iwata, Hironobu Akita, Yoshitake Sato, Kimiko Ubukata, Nahoko Chiba, Keiko Hasegawa

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We surveyed the epidemiology of pediatric bacterial meningitis between January 2003 and December 2004 in Japan, with the following results: Bacterial meningitis cases numbered 233 (132 boys, 98 girls, and 3 unidentified), equivalent to 1.13-1.6 children of 1000 hospitalized in pediatrics per year. The age distribution for the infections was the highest under 1 year of age, decreasing with increasing age. Haemophilus influenzae was the most common pathogen, followed by Streptococcus pneumoniae, group B streptococcus, and Escherichia coli. The relationship between causactive pathogens and age distribution was as follows: group B. streptococcus and E. coli were major pathogens below 4 months of age and H. influenzae and S. pneumoniae were major pathogens above 4 months of age. Susceptibility tests at each facility demonstrated that 65.0% of H. influenzae isolates and 83.0% of S. pneumoniae isolates in 2004 were drug-resistant. Ampicillin and cephem antibiotics are currently effective against GBS, E. coli and Listeria so a combination of ampicillin and cephem antibiotics is used first line at many facilities for patients below 4 months of age. A combination of carbapenem which showed effective against PRSP and cephem which showed effective against H. influenzae is the first choice in childhood bacterial meningitis for patients above 4 months of age.

Original languageEnglish
Pages (from-to)27-38
Number of pages12
JournalKansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Volume80
Issue number1
Publication statusPublished - 2006
Externally publishedYes

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Bacterial Meningitides
Haemophilus influenzae
Japan
Streptococcus pneumoniae
Pediatrics
Streptococcus agalactiae
Age Distribution
Ampicillin
Escherichia coli
Anti-Bacterial Agents
Listeria
Carbapenems
Hospitalized Child
Streptococcus
Epidemiology
Infection
Pharmaceutical Preparations

Cite this

Sunakawa, K., Nonoyama, M., Ooishi, T., Iwata, S., Akita, H., Sato, Y., ... Hasegawa, K. (2006). Trends in pediatric bacterial meningitis in Japan (2003-2004). Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 80(1), 27-38.

Trends in pediatric bacterial meningitis in Japan (2003-2004). / Sunakawa, Keisuke; Nonoyama, Masato; Ooishi, Tomohiro; Iwata, Satoshi; Akita, Hironobu; Sato, Yoshitake; Ubukata, Kimiko; Chiba, Nahoko; Hasegawa, Keiko.

In: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, Vol. 80, No. 1, 2006, p. 27-38.

Research output: Contribution to journalArticle

Sunakawa, K, Nonoyama, M, Ooishi, T, Iwata, S, Akita, H, Sato, Y, Ubukata, K, Chiba, N & Hasegawa, K 2006, 'Trends in pediatric bacterial meningitis in Japan (2003-2004)', Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, vol. 80, no. 1, pp. 27-38.
Sunakawa, Keisuke ; Nonoyama, Masato ; Ooishi, Tomohiro ; Iwata, Satoshi ; Akita, Hironobu ; Sato, Yoshitake ; Ubukata, Kimiko ; Chiba, Nahoko ; Hasegawa, Keiko. / Trends in pediatric bacterial meningitis in Japan (2003-2004). In: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 2006 ; Vol. 80, No. 1. pp. 27-38.
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