Trends in pediatric bacterial meningitis in Japan (2003-2004)

Keisuke Sunakawa, Masato Nonoyama, Tomohiro Ooishi, Satoshi Iwata, Hironobu Akita, Yoshitake Sato, Kimiko Ubukata, Nahoko Chiba, Keiko Hasegawa

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11 Citations (Scopus)


We surveyed the epidemiology of pediatric bacterial meningitis between January 2003 and December 2004 in Japan, with the following results: Bacterial meningitis cases numbered 233 (132 boys, 98 girls, and 3 unidentified), equivalent to 1.13-1.6 children of 1000 hospitalized in pediatrics per year. The age distribution for the infections was the highest under 1 year of age, decreasing with increasing age. Haemophilus influenzae was the most common pathogen, followed by Streptococcus pneumoniae, group B streptococcus, and Escherichia coli. The relationship between causactive pathogens and age distribution was as follows: group B. streptococcus and E. coli were major pathogens below 4 months of age and H. influenzae and S. pneumoniae were major pathogens above 4 months of age. Susceptibility tests at each facility demonstrated that 65.0% of H. influenzae isolates and 83.0% of S. pneumoniae isolates in 2004 were drug-resistant. Ampicillin and cephem antibiotics are currently effective against GBS, E. coli and Listeria so a combination of ampicillin and cephem antibiotics is used first line at many facilities for patients below 4 months of age. A combination of carbapenem which showed effective against PRSP and cephem which showed effective against H. influenzae is the first choice in childhood bacterial meningitis for patients above 4 months of age.

Original languageEnglish
Pages (from-to)27-38
Number of pages12
JournalKansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Issue number1
Publication statusPublished - 2006 Jan

ASJC Scopus subject areas

  • Medicine(all)

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    Sunakawa, K., Nonoyama, M., Ooishi, T., Iwata, S., Akita, H., Sato, Y., Ubukata, K., Chiba, N., & Hasegawa, K. (2006). Trends in pediatric bacterial meningitis in Japan (2003-2004). Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 80(1), 27-38.