TY - JOUR
T1 - Trends in transmitted drug-resistant HIV-1 and demographic characteristics of newly diagnosed patients
T2 - Nationwide surveillance from 2003 to 2008 in Japan
AU - Hattori, Junko
AU - Shiino, Teiichiro
AU - Gatanaga, Hiroyuki
AU - Yoshida, Shigeru
AU - Watanabe, Dai
AU - Minami, Rumi
AU - Sadamasu, Kenji
AU - Kondo, Makiko
AU - Mori, Haruyo
AU - Ueda, Mikio
AU - Tateyama, Masao
AU - Ueda, Atsuhisa
AU - Kato, Shingo
AU - Ito, Toshihiro
AU - Oie, Masayasu
AU - Takata, Noboru
AU - Hayashida, Tsunefusa
AU - Nagashima, Mami
AU - Matsuda, Masakazu
AU - Ibe, Shiro
AU - Ota, Yasuo
AU - Sasaki, Satoru
AU - Ishigatsubo, Yoshiaki
AU - Tanabe, Yoshinari
AU - Koga, Ichiro
AU - Kojima, Yoko
AU - Yamamoto, Masahiro
AU - Fujita, Jiro
AU - Yokomaku, Yoshiyuki
AU - Koike, Takao
AU - Shirasaka, Takuma
AU - Oka, Shinichi
AU - Sugiura, Wataru
N1 - Funding Information:
We are grateful to all the patients who participated in our surveillance study. We thank the members of Japanese Drug Resistance HIV-1 Surveillance Network for their support and helpful discussions: Atsushi Ajisawa, Hitoshi Chiba, Takeshi Fujii, Yuko Fujikawa, Akira Fujita, Katsuyuki Fukutake, Tetsushi Goto, Shuji Hatakeyama, Igen Hongo, Masahide Horiba, Mitsunobu Imai, Tsuguhiro Kaneda, Akiro Kimura, Mitsuru Konishi, Shuzo Matsushita, Motoo Matsuura, Naoko Miyazaki, Itsuhiro Nakagiri, Masaaki Noda, Tsuyoshi Oishi, Chiho Otani, Takeyuki Sato, Satoshi Shirahata, Masashi Taki, Sadahiro Tamashima, Masanori Tei, Kazue Uchida, Kanako Watanabe, Yasuyuki Yamamoto, Kunio Yano, Mihoko Yotsumoto. We also thank Claire Baldwin for her help in preparing the manuscript. This study was supported by a Grant-in-Aid for AIDS research from the Ministry of Health, Labour, and Welfare of Japan ( H19-AIDS-007 ). The sponsor had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
PY - 2010/10
Y1 - 2010/10
N2 - The emergence and transmission of drug-resistant human immunodeficiency virus-1 (HIV-1) compromises antiretroviral treatment for HIV-1. Thus, testing for drug resistance is recommended at diagnosis and before initiating highly active antiretroviral treatment. We conducted an epidemiological study enrolling newly diagnosed patients between 2003 and 2008 in our nationwide surveillance network. In the 6-year study period, the prevalence of drug-resistant HIV-1 among 2573 patients, consisting mainly of Japanese men in their late-30s and infected through male-to-male sexual contacts, followed an increasing trend from 5.9% (16/273) in 2003 to 8.3% (50/605) in 2008. Nucleoside reverse transcriptase inhibitor-associated mutations predominated in each year, with T215 revertants being the most abundant. The predictive factor for drug-resistant HIV-1 transmission was subtype B (OR=2.36; p=0.004), and those for recent HIV-1 infection were male gender (OR=3.79; p=0.009), MSM behavior (OR=1.67; p=0.01), Japanese nationality (OR=2.31; p=0.008), and subtype B (OR=5.64; p<0.05). Continued activities are needed to raise awareness of the risks of HIV-1 infection and complications of drug-resistant strains. Continued surveillance is also needed to understand trends in the HIV-1 epidemic.
AB - The emergence and transmission of drug-resistant human immunodeficiency virus-1 (HIV-1) compromises antiretroviral treatment for HIV-1. Thus, testing for drug resistance is recommended at diagnosis and before initiating highly active antiretroviral treatment. We conducted an epidemiological study enrolling newly diagnosed patients between 2003 and 2008 in our nationwide surveillance network. In the 6-year study period, the prevalence of drug-resistant HIV-1 among 2573 patients, consisting mainly of Japanese men in their late-30s and infected through male-to-male sexual contacts, followed an increasing trend from 5.9% (16/273) in 2003 to 8.3% (50/605) in 2008. Nucleoside reverse transcriptase inhibitor-associated mutations predominated in each year, with T215 revertants being the most abundant. The predictive factor for drug-resistant HIV-1 transmission was subtype B (OR=2.36; p=0.004), and those for recent HIV-1 infection were male gender (OR=3.79; p=0.009), MSM behavior (OR=1.67; p=0.01), Japanese nationality (OR=2.31; p=0.008), and subtype B (OR=5.64; p<0.05). Continued activities are needed to raise awareness of the risks of HIV-1 infection and complications of drug-resistant strains. Continued surveillance is also needed to understand trends in the HIV-1 epidemic.
KW - BED assay
KW - Drug-resistant HIV-1
KW - Newly diagnosed HIV/AIDS patients
KW - Prevalence
KW - Treatment-naïve
UR - http://www.scopus.com/inward/record.url?scp=77956924027&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956924027&partnerID=8YFLogxK
U2 - 10.1016/j.antiviral.2010.07.008
DO - 10.1016/j.antiviral.2010.07.008
M3 - Article
C2 - 20692295
AN - SCOPUS:77956924027
SN - 0166-3542
VL - 88
SP - 72
EP - 79
JO - Antiviral Research
JF - Antiviral Research
IS - 1
ER -
