Triacylglyceride physiology in the short-finned eel, Anguilla australis--the effects of androgen

Erin L. Damsteegt, Yuichi Ozaki, Sally P A McCormick, P. Mark Lokman

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The importance of androgens (especially 11-ketotestosterone) during previtellogenesis in eels is well established. In wild pubertal migrants, circulating 11-ketotestosterone levels correlate with a number of morphological and molecular changes. Here, we test the prediction that this correlation represents a causal relationship by artificially raising the levels of circulating 11-ketotestosterone in prepubertal nonmigratory female and pubertal, migratory male short-finned eels (Anguilla australis) using sustained-release hormone implants. In females, increases in hepatosomatic index and transcript copy numbers of hepatic apolipoprotein B and microsomal triacylglyceride transfer protein indicated increased repackaging of endogenously sourced triacylglycerides. These changes in liver measures were reflected in increased concentrations of serum triacylglycerides. However, despite a small increase in gonadosomatic index, ovarian lipoprotein receptor transcript abundances were not affected by 11-ketotestosterone. Interestingly, no such changes in hepatic gene expression were detected in a dose-response experiment using males. We propose that the androgens are inducing the observed changes in previtellogenic females, although it remains unclear to what extent these effects are direct or indirect.

Original languageEnglish
Pages (from-to)R422-R431
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume310
Issue number5
DOIs
Publication statusPublished - 2016 Mar 1

Fingerprint

Anguilla
Eels
Androgens
Liver
Lipoprotein Receptors
Apolipoproteins B
Hormones
Gene Expression
11-ketotestosterone
Serum
Proteins

Keywords

  • 11-ketotestosterone
  • androgen receptor
  • apolipoprotein b
  • apolipoprotein e
  • fatty acid transport protein
  • lipoprotein lipase
  • low-density lipoprotein receptor
  • microsomal triacylglyceride transfer protein
  • time-course experiment
  • triacylglyceride
  • very-low density lipoprotein
  • vitellogenin receptor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Triacylglyceride physiology in the short-finned eel, Anguilla australis--the effects of androgen. / Damsteegt, Erin L.; Ozaki, Yuichi; McCormick, Sally P A; Lokman, P. Mark.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 310, No. 5, 01.03.2016, p. R422-R431.

Research output: Contribution to journalArticle

Damsteegt, Erin L. ; Ozaki, Yuichi ; McCormick, Sally P A ; Lokman, P. Mark. / Triacylglyceride physiology in the short-finned eel, Anguilla australis--the effects of androgen. In: American Journal of Physiology - Heart and Circulatory Physiology. 2016 ; Vol. 310, No. 5. pp. R422-R431.
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