Trichomonas foetus meningoencephalitis after allogeneic peripheral blood stem cell transplantation

Shinichiro Okamoto, Masatoshi Wakui, H. Kobayashi, N. Sato, A. Ishida, M. Tanabe, T. Takeuchi, S. Fukushima, T. Yamada, Y. Ikeda

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

A 34-year-old man with refractory acute myelogenous leukemia underwent allogeneic peripheral blood stem cell transplantation (PBSCT) from his HLA-matched sibling. Engraftment was prompt and no acute GVHD developed. However, high fever persisted even after engraftment, and the patient developed headache, diplopia, vertigo and nuchal rigidity on day 20 posttransplant. Cerebrospinal fluid (CSF) showed pleocytosis with no detectable microorganisms. Despite therapy with broad-spectrum antibiotics, antifungal agents and antituberculous drugs, he developed rapid mental deterioration with seizures and died on day 40. Just prior to his death, trichomonads were isolated from both CSF and urine. Scanning electron microscopic examination identified the trichomonad as Trichomonas foetus. At autopsy, trichomonads were detected histopathologically in an area involving meningoencephalitis. To our knowledge, this is the first case of T. foetus meningoencephalitis in a recipient of allogeneic PBSCT and, more importantly, the first human case of T. foetus infection.

Original languageEnglish
Pages (from-to)89-91
Number of pages3
JournalBone Marrow Transplantation
Volume21
Issue number1
Publication statusPublished - 1998 Jan 1

Fingerprint

Trichomonas
Peripheral Blood Stem Cell Transplantation
Meningoencephalitis
Fetus
Cerebrospinal Fluid
Muscle Rigidity
Diplopia
Antifungal Agents
Vertigo
Leukocytosis
Acute Myeloid Leukemia
Headache
Siblings
Autopsy
Seizures
Fever
Urine
Electrons
Anti-Bacterial Agents
Infection

Keywords

  • Allogeneic transplantation
  • Infection
  • Meningitis
  • Peripheral blood stem cell
  • Trichomonad

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Trichomonas foetus meningoencephalitis after allogeneic peripheral blood stem cell transplantation. / Okamoto, Shinichiro; Wakui, Masatoshi; Kobayashi, H.; Sato, N.; Ishida, A.; Tanabe, M.; Takeuchi, T.; Fukushima, S.; Yamada, T.; Ikeda, Y.

In: Bone Marrow Transplantation, Vol. 21, No. 1, 01.01.1998, p. 89-91.

Research output: Contribution to journalArticle

Okamoto, S, Wakui, M, Kobayashi, H, Sato, N, Ishida, A, Tanabe, M, Takeuchi, T, Fukushima, S, Yamada, T & Ikeda, Y 1998, 'Trichomonas foetus meningoencephalitis after allogeneic peripheral blood stem cell transplantation', Bone Marrow Transplantation, vol. 21, no. 1, pp. 89-91.
Okamoto, Shinichiro ; Wakui, Masatoshi ; Kobayashi, H. ; Sato, N. ; Ishida, A. ; Tanabe, M. ; Takeuchi, T. ; Fukushima, S. ; Yamada, T. ; Ikeda, Y. / Trichomonas foetus meningoencephalitis after allogeneic peripheral blood stem cell transplantation. In: Bone Marrow Transplantation. 1998 ; Vol. 21, No. 1. pp. 89-91.
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