Trierixin, a novel inhibitor of ER stress-induced XBP1 activation from Streptomyces sp. II. Structure elucidation

Yushi Futamura, Etsu Tashiro, Naoka Hironiwa, Jun Kohno, Maki Nishio, Kazutoshi Shindo, Masaya Imoto

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Trierixin, a new member of the triene-ansamycin group, has been isolated from the fermentation broth of Streptomyces sp. AC654 as an inhibitor of ER stress-induced XBP1 activation. The structure of trierixin was determined on the basis of its spectroscopical and chemical properties. Trierixin possessed a 21-membered macrocyclic lactam, which contains a methylthio-benzenediol structure, and a cyclohexanecarbonylalanine moiety. Trierixin is thus elucidated as 21-thiomethylmycotrienin II.

Original languageEnglish
Pages (from-to)582-585
Number of pages4
JournalJournal of Antibiotics
Volume60
Issue number9
DOIs
Publication statusPublished - 2007 Sep

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Streptomyces
Macrocyclic Lactams
Rifabutin
Fermentation
trierixin

Keywords

  • ER stress
  • Triene-ansamycin
  • Trierixin
  • XBP1

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Molecular Medicine

Cite this

Trierixin, a novel inhibitor of ER stress-induced XBP1 activation from Streptomyces sp. II. Structure elucidation. / Futamura, Yushi; Tashiro, Etsu; Hironiwa, Naoka; Kohno, Jun; Nishio, Maki; Shindo, Kazutoshi; Imoto, Masaya.

In: Journal of Antibiotics, Vol. 60, No. 9, 09.2007, p. 582-585.

Research output: Contribution to journalArticle

Futamura, Yushi ; Tashiro, Etsu ; Hironiwa, Naoka ; Kohno, Jun ; Nishio, Maki ; Shindo, Kazutoshi ; Imoto, Masaya. / Trierixin, a novel inhibitor of ER stress-induced XBP1 activation from Streptomyces sp. II. Structure elucidation. In: Journal of Antibiotics. 2007 ; Vol. 60, No. 9. pp. 582-585.
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AU - Imoto, Masaya

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