Trierixin, a novel inhibitor of ER stress-induced XBP1 activation from Streptomyces sp. II. Structure elucidation

Yushi Futamura, Etsu Tashiro, Naoka Hironiwa, Jun Kohno, Maki Nishio, Kazutoshi Shindo, Masaya Imoto

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Trierixin, a new member of the triene-ansamycin group, has been isolated from the fermentation broth of Streptomyces sp. AC654 as an inhibitor of ER stress-induced XBP1 activation. The structure of trierixin was determined on the basis of its spectroscopical and chemical properties. Trierixin possessed a 21-membered macrocyclic lactam, which contains a methylthio-benzenediol structure, and a cyclohexanecarbonylalanine moiety. Trierixin is thus elucidated as 21-thiomethylmycotrienin II.

Original languageEnglish
Pages (from-to)582-585
Number of pages4
JournalJournal of Antibiotics
Volume60
Issue number9
DOIs
Publication statusPublished - 2007 Sep 1

Keywords

  • ER stress
  • Triene-ansamycin
  • Trierixin
  • XBP1

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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    Futamura, Y., Tashiro, E., Hironiwa, N., Kohno, J., Nishio, M., Shindo, K., & Imoto, M. (2007). Trierixin, a novel inhibitor of ER stress-induced XBP1 activation from Streptomyces sp. II. Structure elucidation. Journal of Antibiotics, 60(9), 582-585. https://doi.org/10.1038/ja.2007.74